Protein identification and
characterization |
Identification and characterization
with peptide mass fingerprinting data |
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Aldente - Identify proteins with peptide mass
fingerprinting data. A new, fast and powerful tool
that takes advantage of Hough transformation for
spectra recalibration and outlier exclusion.
Download the stand-alone version
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FindMod - Predict potential protein
post-translational modifications and potential
single amino acid substitutions in peptides.
Experimentally measured peptide masses are compared
with the theoretical peptides calculated from a
specified Swiss-Prot entry or from a user-entered
sequence, and mass differences are used to better
characterize the protein of interest.
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FindPept - Identify peptides that result from
unspecific cleavage of proteins from their
experimental masses, taking into account artefactual
chemical modifications, post-translational
modifications (PTM) and protease autolytic cleavage
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GlycoMod - Predict possible oligosaccharide
structures that occur on proteins from their
experimentally determined masses (can be used for
free or derivatized oligosaccharides and for
glycopeptides)
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Mascot - Peptide mass fingerprint from Matrix
Science Ltd., London
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PepMAPPER - Peptide mass fingerprinting tool
from UMIST, UK
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PFMUTS - Shows the possible single and double
mutations of a peptide fragment from MALDI peptide
mass fingerprinting
- ProFound
- Search known protein sequences with peptide mass
information from Rockefeller and NY Universities [or
from
Genomic Solutions]
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ProteinProspector - UCSF tools for peptide
masses data (MS-Fit, MS-Pattern, MS-Digest, etc.)
|
Identification and characterization
with MS/MS data |
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Popitam - Identification and characterization
tool for peptides with unexpected modifications
(e.g. post-translational modifications or mutations)
by tandem mass spectrometry
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Phenyx - Protein and peptide
identification/characterization from MS/MS data from
GeneBio, Switzerland
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Mascot - Sequence query and MS/MS ion search
from Matrix Science Ltd., London
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OMSSA - MS/MS peptide spectra identification by
searching libraries of known protein sequences
- PepFrag
- Search known protein sequences with peptide
fragment mass information from Rockefeller and NY
Universities [or from
Genomic
Solutions]
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ProteinProspector - UCSF tools for fragment-ion
masses data (MS-Tag, MS-Seq, MS-Product, etc.)
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SearchXLinks - Analysis of mass spectra of
modified, cross-linked, and digested proteins whose
amino acid sequence is known, from Caesar, Germany
|
Identification with isoelectric point,
molecular weight and/or amino acid composition |
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AACompIdent - Identify a protein by its amino
acid composition
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AACompSim - Compare the amino acid composition
of a UniProtKB/Swiss-Prot entry with all other
entries
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TagIdent - Identify proteins with isoelectric
point (pI), molecular weight (Mw) and
sequence tag, or generate a list of proteins close
to a given pI and Mw
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MultiIdent - Identify proteins with isoelectric
point (pI), molecular weight (Mw),
amino acid composition, sequence tag and peptide
mass fingerprinting data
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Other prediction or characterization
tools |
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ProtParam - Physico-chemical parameters of a
protein sequence (amino-acid and atomic
compositions, isoelectric point, extinction
coefficient, etc.)
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Compute pI/Mw - Compute the theoretical
isoelectric point (pI) and molecular weight (Mw)
from a UniProt Knowledgebase entry or for a user
sequence
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GlycanMass - Calculate the mass of an
oligosaccharide structure
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PeptideCutter - Predicts potential protease and
cleavage sites and sites cleaved by chemicals in a
given protein sequence
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PeptideMass - Calculate masses of peptides and
their post-translational modifications for a
UniProtKB/Swiss-Prot or UniProtKB/TrEMBL entry or
for a user sequence
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IsotopIdent - Predicts the theoretical isotopic
distribution of a peptide, protein, polynucleotide
or chemical compound
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Other
proteomics tools |
Other tools for MS data
(vizualisation, quantitation, analysis, etc.) |
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MALDIPepQuant - Quantify MALDI peptides
(SILAC) from
Phenyx
output
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MSight - Mass Spectrometry Imager
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pIcarver - Visualize theoretical distributions
of peptide pI on a given pH range and generate
fractions with similar peptide frequencies
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ImageMaster / Melanie - Software for 2-D PAGE
analysis
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Make2D-DB II - A package to build a web-based
proteomics database
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