ADAN database

 

Scanning Information and Binding Energy of Known Targets

Matrix information:                                                    (Help)
ADAN-name: 4GBQ2.PDB
Scoring matrix: 4GBQ2_mat
Uniprot code: Q60631
Genome source: Mus musculus
Wild-type ligand: VPPPVPPRRR
Foldx wt ligand score: 1.85
Foldx random average score for Mus musculus: 11.797

Available information for Q60631 in MINT (Nov 2008):
Nš of interacting proteins: 32
 Proteins belonging to other specie: 6
Nš of interactions described: 55
 Interactions with other species: 12

Genome scanning information:
Subcellular location: True
Proteins in genome Mus musculus: 58346
Proteins located in other compartments: 13502
Proteins considered as fragments or having non-standard amino acids: 13900
Total scanned proteins: 30944
 Total fragments: 13390911
Proteins after random average filtering: 30940
 Total fragments: 6647284
Proteins after disorder filtering: 22380
 Total fragments: 611695
Proteins after pattern filtering: 15875
 Total fragments: 184687
Proteins after MINT filtering: 13
 Total fragments: 329


Prediction of know targets:

Ligand peptide Sequence Foldx score ΔGbinding ΔΔG
Reference wt

VPPPVPPRRR

1.85

-15.69

0.00

Best peptides

APPERPRNRR

0.00

-10.76

4.93

         
Interactors      
Q62245

VPPPVPPRRR

1.85

-13.61

2.08

PPPVPPRRRP

5.01

-13.49

2.20

SPPAIPPRQP

5.78

-13.39

2.30

P04925

NQWNKPSKPK

10.82

-6.01

9.68

Q923U0

LPSSHPVLKD

7.29

-7.64

8.05

ISPNRPTSVP

7.85

-9.56

6.13

SEPSAPSCDL

8.09

-5.97

9.72

Q02384

IPPPLPPRKK

4.55

-12.05

3.64

PAPPVPPRQN

4.65

-13.96

1.73

PPPLPPRKKF

4.69

-10.86

4.83

Q91ZZ2

SPPALPPKKR

4.09

-11.99

3.70

PKPPLPGIRV

4.97

-11.64

4.05

PPPALPPKQR

4.98

-11.99

3.70

Q60992

PPTGRPPSRE

6.87

-8.91

6.78

RPPTGRPPSR

8.91

-6.40

9.29

NPAPPGKPVL

9.43

-5.23

10.46

O35716

AAPVRPRPCP

6.19

-8.99

6.70

PAPAPGDTHF

7.77

-6.30

9.39

PCPAVPAPAP

7.95

-7.18

8.51

Q80U87

APPSTPPTHK

5.90

-9.12

6.57

YPPEMAPSSA

6.80

-7.59

8.10

LEEPVPSKLP

7.98

-8.13

7.56

Q9EQ32

RPPRVPPRAA

4.73

-12.80

2.89

GPPPPPDNEP

6.75

-10.75

4.94

NRPPVPVPRP

6.76

-10.25

5.44

Q9Z1S8

PPPRPPKPSQ

7.09

-8.82

6.87

PRPPKPSQAE

7.16

-10.84

4.85

FQPGSPSPHR

7.39

-7.34

8.35

P27870

IPPPPGAFGP

9.79

-7.27

8.42

GIPPPPGAFG

10.11

-7.16

8.53

YYGIPPPPGA

10.17

-5.06

10.63

Q62077

DGPDGMPVIY

10.45

-4.97

10.72

DCWDGPDGMP

10.48

-4.53

11.16

Q9QYY0

TPPRRPVPVA

5.45

-10.78

4.91

SSPKTPPRRP

6.35

-11.44

4.25

MNPNSPPRQH

6.63

-11.20

4.49

 


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