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Scanning Information and Binding Energy of Known Targets

Matrix information:                                                    (Help)
ADAN-name: 2OI32.PDB
Scoring matrix: 2OI32_mat
Uniprot code: P08631
Genome source: Homo sapiens
Wild-type ligand: HSKYPLPPLPSL
Foldx wt ligand score: 7.14
Foldx random average score for Homo sapiens: 15.972

Available information for P08631 in MINT (Nov 2008):
Nº of interacting proteins: 16
 Proteins belonging to other specie: 7
Nº of interactions described: 37
 Interactions with other species: 17

Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 7698
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 40363
 Total fragments: 18147411
Proteins after random average filtering: 40338
 Total fragments: 9766835
Proteins after disorder filtering: 28662
 Total fragments: 560049
Proteins after pattern filtering: 20915
 Total fragments: 220881
Proteins after MINT filtering: 6
 Total fragments: 190


Prediction of know targets:

Ligand peptide Sequence Foldx score ΔGbinding ΔΔG
Reference wt

HSKYPLPPLPSL

7.14

-14.55

0.00

Best peptides

PFMMRLPWLRKN

0.00

-18.12

-3.57

         
Interactors      
Q92556

QIPDAPPPIPKE

11.96

-12.41

2.14

DAPPPIPKEPSN

13.56

-11.07

3.48

IPDAPPPIPKEP

15.76

-11.37

3.18

O43516

PQRNRMPPPRPD

7.17

-15.20

-0.65

PRSGPRPPLPPD

9.88

-14.63

-0.08

PPQNNKPPVPST

10.48

-13.43

1.12

Q13177

EDKPPAPPVRMS

11.97

-12.26

2.29

PEKDGFPSGTPA

13.65

-10.00

4.55

NHSLKPLPSVPE

13.86

-8.35

6.20

P42768

ERRGGLPPLPLH

8.37

-14.88

-0.33

RRQLPPPPTPAN

9.46

-13.44

1.11

GNQLPRPPIVGG

9.72

-12.34

2.21

Q13444

PPRKPLPADPQG

8.09

-14.62

-0.07

PSERPGPPQRAL

11.18

-11.88

2.67

RAAQSGPSERPG

11.92

-11.56

2.99

P21860

PGIAPGPEPHGL

9.94

-12.56

1.99

PIMPTAGTTPDE

12.56

-9.81

4.74

CPLHPVPIMPTA

12.65

-10.20

4.35

 


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