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Matrix information:
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ADAN-name: 2O022.PDB
Scoring matrix: 2O022_mat
Uniprot code: P63104
Genome source: Homo sapiens
Wild-type ligand: GHGQGLLDALDLAS
Foldx wt ligand score: 11.21
Foldx random average score for Homo sapiens: 34.190 Available information for P63104 in MINT (Nov 2008):
Nš of interacting proteins: 310
Proteins belonging to other specie: 3
Nš of interactions described: 374
Interactions with other species: 6
Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 7744
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 40317
Total fragments: 18049599
Proteins after random average filtering: 40272
Total fragments: 9735803
Proteins after disorder filtering: 27898
Total fragments: 675555
Proteins after pattern filtering: 3771
Total fragments: 15380
Proteins after MINT filtering: 31
Total fragments: 204
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
GHGQGLLDALDLAS |
11.21
|
-24.06 |
0.00 |
| Best peptides |
GNMWYMMMALMLsG |
0.00
|
-25.99 |
-1.93 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| Q08211 |
GVSRGGFRGNSGGD |
20.88
|
-13.31 |
10.75 |
|
GGYRGVSRGGFRGN |
22.21
|
-15.24 |
8.82 |
|
AGVGGGYRGVSRGG |
22.99
|
-11.17 |
12.89 |
| Q5T200 |
QKRSSSLGSNRSNR |
27.27
|
-16.23 |
7.83 |
|
LGSNRSNRSHTSGR |
27.81
|
-15.03 |
9.03 |
|
RSNRSHTSGRLRSP |
27.88
|
-8.48 |
15.58 |
| P54253 |
SPQNTGRTASPPAI |
30.87
|
-7.75 |
16.31 |
|
SSPQNTGRTASPPA |
33.94
|
-6.01 |
18.05 |
|
NTGRTASPPAIPVH |
34.10
|
-7.70 |
16.36 |
| Q14432 |
RPYSQGNPADEPLE |
25.62
|
-17.92 |
6.14 |
|
CSSCGRPYSQGNPA |
30.82
|
-13.98 |
10.08 |
|
VICSSCGRPYSQGN |
31.25
|
-10.88 |
13.18 |
| P47736 |
GKSPTRKKSGPFGS |
28.25
|
-13.78 |
10.28 |
|
KSPTRKKSGPFGSR |
28.57
|
-12.21 |
11.85 |
|
SPTRKKSGPFGSRR |
32.71
|
-7.51 |
16.55 |
| P58340 |
GNTRMRSVGHENPG |
26.70
|
-19.49 |
4.57 |
|
RHNLGNTRMRSVGH |
26.93
|
-14.75 |
9.31 |
|
NLGNTRMRSVGHEN |
27.32
|
-19.03 |
5.03 |
| P16471 |
CWWRPGTDGGLPTN |
26.73
|
-12.50 |
11.56 |
|
TFTCWWRPGTDGGL |
27.45
|
-13.70 |
10.36 |
|
WWRPGTDGGLPTNY |
33.00
|
-7.52 |
16.54 |
| Q9UDY2 |
RSRLNSHGGRSRSW |
23.28
|
-14.71 |
9.35 |
|
RLNSHGGRSRSWED |
24.74
|
-15.71 |
8.35 |
|
YSERSRLNSHGGRS |
28.59
|
-16.15 |
7.91 |
| O75044 |
RSDSHGLSSSLTDS |
20.10
|
-18.70 |
5.36 |
|
KTFRSDSHGLSSSL |
23.35
|
-14.95 |
9.11 |
|
IRKTFRSDSHGLSS |
24.72
|
-15.00 |
9.06 |
| P30304 |
ERDSSEPGNFIPLF |
32.70
|
-18.65 |
5.41 |
| Q7KZI7 |
RKKTTPTPSTNSVL |
27.14
|
-12.64 |
11.42 |
|
SNCEVPRPSTAPQR |
28.40
|
-14.08 |
9.98 |
|
GLERKKTTPTPSTN |
32.18
|
-11.82 |
12.24 |
| Q86YZ3 |
RSSSSGQHGSGLGE |
22.72
|
-10.27 |
13.79 |
|
RSSSSGRHGSGSGQ |
24.35
|
-10.56 |
13.50 |
|
GSGRSSSSGRHGSG |
24.95
|
-16.32 |
7.74 |
| Q7Z6B7 |
PPIRRSTSSGQYTG |
21.66
|
-20.73 |
3.33 |
|
PIRRSTSSGQYTGF |
23.20
|
-18.61 |
5.45 |
|
RSTSSGQYTGFNDH |
25.05
|
-12.13 |
11.93 |
| O43524 |
QRSSSFPYTTKGSG |
27.23
|
-10.31 |
13.75 |
|
PTGGLMQRSSSFPY |
27.40
|
-14.54 |
9.52 |
|
RSSSFPYTTKGSGL |
27.81
|
-12.11 |
11.95 |
| Q9Y4H2 |
RPWTPGQPGGLVGC |
24.99
|
-13.95 |
10.11 |
|
GRPWTPGQPGGLVG |
27.34
|
-14.37 |
9.69 |
|
APQGRPWTPGQPGG |
29.60
|
-10.89 |
13.17 |
| Q6DD88 |
PLTGFSWRGGSDPE |
32.04
|
-9.13 |
14.93 |
|
LTGFSWRGGSDPET |
32.81
|
-15.35 |
8.71 |
| O96013 |
SSRDKRPLSGPDVG |
27.33
|
-15.74 |
8.32 |
|
PKSSREGSGGPQES |
27.34
|
-11.07 |
12.99 |
|
RPKSSREGSGGPQE |
27.37
|
-11.84 |
12.22 |
| Q14764 |
GQPLGRRVASGPSP |
26.78
|
-14.21 |
9.85 |
|
PLGRRVASGPSPGE |
28.26
|
-11.14 |
12.92 |
|
GRRVASGPSPGEGI |
30.34
|
-8.40 |
15.66 |
| O00571 |
RSDSRGKSSFFSDR |
20.10
|
-17.83 |
6.23 |
|
SSFGSRSDSRGKSS |
23.23
|
-15.47 |
8.59 |
|
AYSSFGSRSDSRGK |
25.58
|
-12.75 |
11.31 |
| Q7L8J4 |
GTRSGGRRGSDGGA |
21.34
|
-16.09 |
7.97 |
|
TRSGGRRGSDGGAR |
25.37
|
-14.27 |
9.79 |
|
RSGGRRGSDGGARG |
30.71
|
-9.87 |
14.19 |
| Q15154 |
QRSTSAPSASVGLA |
24.82
|
-15.21 |
8.85 |
|
QRSVDQRSTSAPSA |
26.59
|
-10.40 |
13.66 |
|
PQRSVDQRSTSAPS |
27.57
|
-18.23 |
5.83 |
| Q5VV41 |
PLPGGGNRSSSVPH |
29.14
|
-11.59 |
12.47 |
| O60825 |
RRPRNYSVGSRPLK |
29.04
|
-15.41 |
8.65 |
|
RNYSVGSRPLKPLS |
29.46
|
-12.15 |
11.91 |
|
SNTIRRPRNYSVGS |
29.67
|
-13.17 |
10.89 |
| Q04637 |
RTASTPTPPQTGGG |
32.02
|
-10.85 |
13.21 |
| Q9UQL6 |
RTQSSPAAPGGMKS |
32.13
|
-8.05 |
16.01 |
| Q6Y7W6 |
GAPRGRSSSRGRGR |
21.89
|
-13.48 |
10.58 |
|
GRSSSRGRGRGRGE |
23.26
|
-15.00 |
9.06 |
|
PRGRSSSRGRGRGR |
24.04
|
-15.91 |
8.15 |
| O60292 |
REHSNPSPSQDTDG |
27.26
|
-14.36 |
9.70 |
|
LREHSNPSPSQDTD |
33.12
|
-9.84 |
14.22 |
|
KRPVSFPETPYTVS |
33.20
|
-9.02 |
15.04 |
| O95644 |
GRGETLGPAPRAGG |
27.96
|
-13.95 |
10.11 |
|
PAAAVFGRGETLGP |
28.02
|
-14.41 |
9.65 |
|
AAVFGRGETLGPAP |
29.97
|
-15.11 |
8.95 |
| O00750 |
GKPVARSKTMPPQV |
31.16
|
-13.85 |
10.21 |
| Q8WUI4 |
PLSRAQSSPAAPAS |
27.39
|
-14.10 |
9.96 |
|
SRAQSSPAAPASLS |
29.85
|
-12.30 |
11.76 |
|
GLHWPLSRTRSEPL |
31.21
|
-17.10 |
6.96 |
| Q5T5U3 |
SRTTSPPLSIPTTH |
33.55
|
-6.98 |
17.08 |
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