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Matrix information:
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ADAN-name: 2IUH2.PDB
Scoring matrix: 2IUH2_mat
Uniprot code: P27986
Genome source: Homo sapiens
Wild-type ligand: TNEyMDMK
Foldx wt ligand score: 4.66
Foldx random average score for Homo sapiens: 18.578 Available information for P27986 in MINT (Nov 2008):
Nš of interacting proteins: 27
Proteins belonging to other specie: 5
Nš of interactions described: 83
Interactions with other species: 11
Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 1
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48060
Total fragments: 22199903
Proteins after random average filtering: 48044
Total fragments: 11471029
Proteins after disorder filtering: 36004
Total fragments: 768619
Proteins after pattern filtering: 15671
Total fragments: 59826
Proteins after MINT filtering: 12
Total fragments: 127
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
TNEyMDMK |
4.66
|
-17.92 |
0.00 |
| Best peptides |
PDyyMsMy |
0.00
|
-20.58 |
-2.66 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P00533 |
PPLMLYNP |
13.64
|
-11.03 |
6.89 |
|
TTYQMDVN |
15.40
|
-10.22 |
7.70 |
|
LMLYNPTT |
16.16
|
-9.75 |
8.17 |
| P62993 |
RNYVTPVN |
16.85
|
-8.64 |
9.28 |
|
PRNYVTPV |
18.06
|
-8.07 |
9.85 |
| P22681 |
EEDTEYMT |
11.82
|
-11.83 |
6.09 |
|
YDDDDDER |
14.78
|
-10.85 |
7.07 |
|
DTEYMTPS |
15.37
|
-10.67 |
7.25 |
| Q07666 |
PAPETYEE |
17.62
|
-6.08 |
11.84 |
| P35568 |
DDGYMPMS |
7.76
|
-16.48 |
1.44 |
|
PNGYMMMS |
8.51
|
-15.67 |
2.25 |
|
SGDYMPMS |
10.16
|
-12.93 |
4.99 |
| P42336 |
RAMYVYPP |
17.66
|
-8.85 |
9.07 |
|
YHGGEPLC |
18.02
|
-6.37 |
11.55 |
| Q9UQC2 |
EDNYVPMN |
8.66
|
-16.76 |
1.16 |
|
EENYVPMQ |
9.90
|
-14.54 |
3.38 |
|
QSVYIPMS |
12.55
|
-12.30 |
5.62 |
| Q9Y5K6 |
PSVYLSTP |
15.88
|
-9.29 |
8.63 |
|
PKPSVYLS |
16.11
|
-8.30 |
9.62 |
|
SVYLSTPS |
17.65
|
-6.99 |
10.93 |
| O15455 |
SSHYLCNT |
16.66
|
-4.69 |
13.23 |
|
SHYLCNTP |
16.77
|
-7.38 |
10.54 |
|
YLCNTPPH |
18.49
|
-7.80 |
10.12 |
| P04626 |
PEYLTPQG |
14.31
|
-10.50 |
7.42 |
|
TDGYVAPL |
14.49
|
-10.62 |
7.30 |
|
QPEYVNQP |
15.01
|
-10.02 |
7.90 |
| P21860 |
DEDYEYMN |
11.01
|
-14.06 |
3.86 |
|
SSGYMPMN |
11.05
|
-12.05 |
5.87 |
|
GGDYAAMG |
13.15
|
-10.57 |
7.35 |
| Q13480 |
EENYVPMN |
9.74
|
-15.66 |
2.26 |
|
VDSSLYNL |
14.59
|
-9.82 |
8.10 |
|
PPYQLINV |
16.22
|
-7.95 |
9.97 |
|
