|
Matrix information:
(Help)
ADAN-name: 2H8H3.PDB
Scoring matrix: 2H8H3_mat
Uniprot code: P12931
Genome source: Homo sapiens
Wild-type ligand: VCPTSKPQTQGLAKDA
Foldx wt ligand score: 8.22
Foldx random average score for Homo sapiens: 14.504 Available information for P12931 in MINT (Nov 2008):
Nš of interacting proteins: 50
Proteins belonging to other specie: 11
Nš of interactions described: 106
Interactions with other species: 20
Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 1
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48060
Total fragments: 21815789
Proteins after random average filtering: 48006
Total fragments: 12599217
Proteins after disorder filtering: 30423
Total fragments: 600735
Proteins after pattern filtering: 21644
Total fragments: 215819
Proteins after MINT filtering: 27
Total fragments: 501
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
VCPTSKPQTQGLAKDA |
8.22
|
-9.27 |
0.00 |
| Best peptides |
EWDEDMPETYGWMFRW |
0.00
|
-13.24 |
-3.97 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| Q13177 |
KPPAPPVRMSSTIFST |
11.03
|
-11.35 |
-2.08 |
|
EDKPPAPPVRMSSTIF |
11.57
|
-7.99 |
1.28 |
|
DKPPAPPVRMSSTIFS |
12.15
|
-9.49 |
-0.22 |
| Q8TBB1 |
YVSSAEDGQPAISPVD |
13.33
|
-8.60 |
0.67 |
|
EDGQPAISPVDSGRSN |
14.03
|
-6.68 |
2.59 |
| Q8WUM4 |
QYNMPYPPVYHQSPGQ |
8.75
|
-11.11 |
-1.84 |
|
PGYPGYCQMPMPMGYN |
10.08
|
-9.95 |
-0.68 |
|
PPPPVLPANRAPSATA |
11.05
|
-8.93 |
0.34 |
| Q16832 |
CSGVVKPVQPSGPEGV |
13.56
|
-7.82 |
1.45 |
| Q05193 |
RGPAPGPPPAGSALGG |
10.53
|
-7.99 |
1.28 |
|
SRPGASPDPFGPPPQV |
11.26
|
-11.14 |
-1.87 |
|
RPNRAPPGVPSRSGQA |
11.96
|
-8.25 |
1.02 |
| P15941 |
TTTPASKSTPFSIPSH |
10.35
|
-8.83 |
0.44 |
|
STPFSIPSHHSDTPTT |
11.37
|
-9.07 |
0.20 |
|
SAPDNRPALGSTAPPV |
12.18
|
-10.40 |
-1.13 |
| P09848 |
TGPHACLHQPDAGPTI |
12.89
|
-7.70 |
1.57 |
|
NGFPDPATGPHACLHQ |
13.26
|
-7.02 |
2.25 |
| P05106 |
PVSPYMYISPPEALEN |
13.11
|
-11.33 |
-2.06 |
| P00533 |
SCQKCDPSCPNGSCWG |
11.43
|
-7.39 |
1.88 |
|
PSRDPHYQDPHSTAVG |
11.79
|
-6.56 |
2.71 |
|
QNPVYHNQPLNPAPSR |
11.79
|
-9.33 |
-0.06 |
| P49407 |
FTFEIPPNLPCSVTLQ |
10.32
|
-9.50 |
-0.23 |
|
HPKPKEEPPHREVPEN |
12.46
|
-10.16 |
-0.89 |
|
PPNLPCSVTLQPGPED |
12.79
|
-7.34 |
1.93 |
| P22681 |
PQRRPLPCTPGDCPSR |
5.60
|
-13.11 |
-3.84 |
|
PSRDKLPPVPSSRLGD |
9.09
|
-13.08 |
-3.81 |
|
SQMEPRPDVPRLGSTF |
9.28
|
-10.50 |
-1.23 |
| P18031 |
PPPEHIPPPPRPPKRI |
11.76
|
-14.11 |
-4.84 |
|
PPPPRPPKRILEPHNG |
13.50
|
-8.90 |
0.37 |
|
IPPPPRPPKRILEPHN |
13.79
|
-11.15 |
-1.88 |
| P03372 |
SPLMLLHPPPQLSPFL |
11.40
|
-12.26 |
-2.99 |
|
PLMLLHPPPQLSPFLQ |
12.11
|
-10.44 |
-1.17 |
|
GQTGLPYGPGSEAAAF |
12.71
|
-6.55 |
2.72 |
| P49023 |
SSPPGGPPKPGSQLDS |
10.61
|
-7.64 |
1.63 |
|
EANSSPPLPGALSPLY |
11.12
|
-8.97 |
0.30 |
|
VPPPVPPPPSSEALNG |
11.33
|
-10.19 |
-0.92 |
| Q05397 |
ENGERLPMPPNCPPTL |
9.83
|
-12.41 |
-3.14 |
|
PPRPGAPGHLGSLASL |
10.77
|
-9.43 |
-0.16 |
|
PKKPPRPGAPGHLGSL |
11.15
|
-10.84 |
-1.57 |
| P50570 |
PGPPLIPVPVGAAASF |
10.31
|
-8.51 |
0.76 |
|
PPIPSRPGPQSVFANS |
10.77
|
-10.00 |
-0.73 |
|
FSAPPIPSRPGPQSVF |
11.17
|
-6.38 |
2.89 |
| Q07666 |
QTPSRQPPLPHRSRGG |
9.43
|
-10.36 |
-1.09 |
|
QPPLPHRSRGGGGGSR |
11.53
|
-6.42 |
2.85 |
|
TQPPPLLPPSATGPDA |
11.68
|
-8.75 |
0.52 |
| Q9C0H9 |
ASGSPPPGLPSGLPSG |
10.09
|
-11.43 |
-2.16 |
|
AAPKSSPRSPGGRRGD |
10.27
|
-8.25 |
1.02 |
|
SKSPPPPPPRRSFPSS |
10.40
|
-11.98 |
-2.71 |
| P55196 |
PPCQPRPASDGVFLSN |
9.00
|
-11.74 |
-2.47 |
|
LPPEKLPYLVELSPDG |
9.38
|
-9.47 |
-0.20 |
|
SEPKKLPGDDRLMKNR |
9.59
|
-12.66 |
-3.39 |
| P00519 |
TDVPEMPHSKGQGESD |
9.39
|
-8.05 |
1.22 |
|
LKKPVLPATPKPQSAK |
9.79
|
-8.97 |
0.30 |
|
PAKSPKPSNGAGVPNG |
10.15
|
-9.26 |
0.01 |
| Q9H5V8 |
NINTEMPRQPKKFQKG |
9.97
|
-11.53 |
-2.26 |
|
INTEMPRQPKKFQKGR |
10.80
|
-8.87 |
0.40 |
|
YNGNINTEMPRQPKKF |
12.36
|
-10.01 |
-0.74 |
| Q13444 |
SGPSERPGPPQRALLA |
9.64
|
-11.91 |
-2.64 |
|
PRKPLPADPQGRCPSG |
10.42
|
-10.45 |
-1.18 |
|
RPTRGDCDLPEFCPGD |
10.49
|
-9.61 |
-0.34 |
| Q06124 |
DQSPLPPCTPTPPCAE |
14.20
|
-8.25 |
1.02 |
| Q9Y5K6 |
PPKKPTPPTKASNLLR |
9.39
|
-9.74 |
-0.47 |
|
RPKMPGRRLPGRFNGG |
11.19
|
-7.88 |
1.39 |
|
PKKPTPPTKASNLLRS |
11.68
|
-9.43 |
-0.16 |
| P56945 |
QYTPMLPNTYQPQPDS |
8.15
|
-12.25 |
-2.98 |
|
IQSRPLPSPPKFTSQD |
10.27
|
-12.14 |
-2.87 |
|
NWTPAQPLAPGRTGGL |
10.50
|
-7.05 |
2.22 |
| P06241 |
GTDPTPQHYPSFGVTS |
13.08
|
-7.61 |
1.66 |
|
GYRYGTDPTPQHYPSF |
13.17
|
-7.40 |
1.87 |
|
TDPTPQHYPSFGVTSI |
13.24
|
-7.62 |
1.65 |
| P21860 |
LHPVPIMPTAGTTPDE |
10.03
|
-7.23 |
2.04 |
|
QSCPLHPVPIMPTAGT |
11.34
|
-6.33 |
2.94 |
|
SLGSTQSCPLHPVPIM |
12.30
|
-6.58 |
2.69 |
|
