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Scanning Information and Binding Energy of Known Targets

Matrix information:                                                    (Help)
ADAN-name: 1ZSG2.PDB
Scoring matrix: 1ZSG2_mat
Uniprot code: Q14155
Genome source: Homo sapiens
Wild-type ligand: PVIAPRPEHTKSVYTRS
Foldx wt ligand score: 9.07
Foldx random average score for Homo sapiens: 18.160

Available information for Q14155 in MINT (Nov 2008):
Nº of interacting proteins: 19
 Proteins belonging to other specie: 3
Nº of interactions described: 31
 Interactions with other species: 3

Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 1
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48060
 Total fragments: 21767509
Proteins after random average filtering: 48001
 Total fragments: 12912779
Proteins after disorder filtering: 30073
 Total fragments: 1027900
Proteins after pattern filtering: 22240
 Total fragments: 425712
Proteins after MINT filtering: 10
 Total fragments: 285


Prediction of know targets:

Ligand peptide Sequence Foldx score ΔGbinding ΔΔG
Reference wt

PVIAPRPEHTKSVYTRS

9.07

-2.01

0.00

Best peptides

RDIARARAAGWRHHRRG

0.00

-1.61

0.40

         
Interactors      
Q13177

EDKPPAPPVRMSSTIFS

12.56

-0.26

1.75

KPPAPPVRMSSTIFSTG

12.58

-1.49

0.52

DPLSANHSLKPLPSVPE

14.82

0.41

2.42

Q13153

RDVATSPISPTENNTTP

10.07

-1.17

0.84

KPPAPPMRNTSTMIGAG

13.50

-1.25

0.76

SKDAGTLNHGSKPLPPN

13.92

3.28

5.29

Q13444

LLGAGSPLPSWPLPNIG

11.45

0.92

2.93

KSQGPAKPPPPRKPLPA

11.50

0.81

2.82

ALLARGTKSQGPAKPPP

11.79

-2.34

-0.33

Q13191

SDGSQAPARPPKPRPRR

9.62

-2.06

-0.05

GSQAPARPPKPRPRRTA

11.00

-0.45

1.56

PPKPRPRRTAPEIHHRK

11.03

-2.54

-0.53

P16333

LTSGLEPSPPQCDYIRP

13.13

0.58

2.59

PLTSGLEPSPPQCDYIR

13.28

0.73

2.74

KPSVPDSASPADDSFVD

13.73

4.70

6.71

P49023

GFMAQGKTGSSSPPGGP

10.27

-0.66

1.35

ADEANSSPPLPGALSPL

10.75

2.31

4.32

QGKTGSSSPPGGPPKPG

11.03

2.46

4.47

Q9Y2X7

SERAEHTPMAPGGSTHR

9.84

-3.71

-1.70

PGPVPTPPLPSERAEHT

15.17

3.38

5.39

PPGPVPTPPLPSERAEH

15.59

2.47

4.48

O14936

PPTSPYLNGDSPESANG

13.98

1.11

3.12

LRVTPPPTSPYLNGDSP

14.20

2.08

4.09

YGDPPEELPDFSEDPTS

15.21

5.50

7.51

Q14161

DGLVPDTAEPHVAPSPT

11.27

3.37

5.38

RPMSMYETGSGQKPYLP

11.84

-0.21

1.80

VPDTAEPHVAPSPTLPS

15.13

3.97

5.98

Q14160

PPWASPSPTSRQSPASP

9.65

-2.43

-0.42

RGGARGHAGNPRDPTDE

9.89

0.44

2.45

GKMAESPCSPSGQQPPS

10.09

0.37

2.38

 


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