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Matrix information:
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ADAN-name: 1Y573.PDB
Scoring matrix: 1Y573_mat
Uniprot code: P12931
Genome source: Homo sapiens
Wild-type ligand: KPQTQGLAKD
Foldx wt ligand score: 6.71
Foldx random average score for Homo sapiens: 12.399 Available information for P12931 in MINT (Nov 2008):
Nš of interacting proteins: 50
Proteins belonging to other specie: 11
Nš of interactions described: 106
Interactions with other species: 20
Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 1
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48060
Total fragments: 22103987
Proteins after random average filtering: 48047
Total fragments: 14100300
Proteins after disorder filtering: 36028
Total fragments: 1435610
Proteins after pattern filtering: 25769
Total fragments: 405832
Proteins after MINT filtering: 27
Total fragments: 989
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
KPQTQGLAKD |
6.71
|
-7.27 |
0.00 |
| Best peptides |
RPYMPGERWF |
0.00
|
-9.02 |
-1.75 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| Q13177 |
KDGFPSGTPA |
7.16
|
-9.02 |
-1.75 |
|
EDKPPAPPVR |
7.73
|
-10.15 |
-2.88 |
|
KPPAPPVRMS |
9.18
|
-10.20 |
-2.93 |
| Q8TBB1 |
EDGQPAISPV |
9.74
|
-5.44 |
1.83 |
|
RSNTPKPLHP |
10.86
|
-8.34 |
-1.07 |
|
GQPAISPVDS |
11.04
|
-4.75 |
2.52 |
| Q8WUM4 |
TPPTPAPRTM |
5.45
|
-9.91 |
-2.64 |
|
YPTYPGYPGY |
6.12
|
-10.18 |
-2.91 |
|
QYNMPYPPVY |
6.38
|
-9.99 |
-2.72 |
| Q16832 |
KPVQPSGPEG |
7.06
|
-9.51 |
-2.24 |
|
PTSPMAPTTY |
7.84
|
-7.51 |
-0.24 |
|
LPTSPMAPTT |
8.33
|
-8.39 |
-1.12 |
| Q05193 |
PPARPGSRGP |
4.79
|
-9.97 |
-2.70 |
|
NRAPPGVPSR |
6.93
|
-10.40 |
-3.13 |
|
RGPAPGPPPA |
7.10
|
-8.11 |
-0.84 |
| P15941 |
VTSAPDNRPA |
7.45
|
-7.73 |
-0.46 |
|
VTSAPDTRPA |
7.66
|
-7.91 |
-0.64 |
|
KSTPFSIPSH |
8.76
|
-7.79 |
-0.52 |
| P09848 |
GVSIWDPRRP |
7.73
|
-8.92 |
-1.65 |
|
FPDPATGPHA |
8.09
|
-8.42 |
-1.15 |
|
HGSSPSLPGV |
10.14
|
-4.28 |
2.99 |
| P05106 |
PVSPYMYISP |
8.95
|
-7.98 |
-0.71 |
|
DTCEKCPTCP |
9.21
|
-6.76 |
0.51 |
| P00533 |
NPAPSRDPHY |
7.89
|
-8.62 |
-1.35 |
|
VPKRPAGSVQ |
8.68
|
-6.65 |
0.62 |
|
YHNQPLNPAP |
8.82
|
-7.72 |
-0.45 |
| P49407 |
FEIPPNLPCS |
7.01
|
-8.67 |
-1.40 |
|
HPKPKEEPPH |
7.73
|
-9.64 |
-2.37 |
|
PKPKEEPPHR |
9.70
|
-6.78 |
0.49 |
| P22681 |
RPPKPFPRRI |
4.25
|
-11.21 |
-3.94 |
|
RPLRPLDTSQ |
4.85
|
-8.33 |
-1.06 |
|
LPPVPSSRLG |
5.60
|
-11.96 |
-4.69 |
| P18031 |
IPPPPRPPKR |
6.38
|
-11.71 |
-4.44 |
|
LEPPPEHIPP |
7.57
|
-10.41 |
-3.14 |
|
AKGEPSLPEK |
8.59
|
-7.37 |
-0.10 |
| P03372 |
QTGLPYGPGS |
8.72
|
-5.96 |
1.31 |
|
LHPPPQLSPF |
8.99
|
-7.05 |
0.22 |
|
HPPPQLSPFL |
9.07
|
-9.63 |
-2.36 |
| P49023 |
QHNPPGFPAD |
7.08
|
-8.53 |
-1.26 |
|
GPPKPGSQLD |
7.72
|
-6.51 |
0.76 |
|
SSSPPGGPPK |
8.36
|
-8.88 |
-1.61 |
| Q05397 |
KPPRPGAPGH |
5.17
|
-10.82 |
-3.55 |
|
KPSRPGYPSP |
5.22
|
-11.01 |
-3.74 |
|
RPGYPSPRSS |
5.66
|
-12.16 |
-4.89 |
| P50570 |
FPAPPQIPSR |
6.23
|
-11.44 |
-4.17 |
|
IPSRPGPQSV |
6.61
|
-6.84 |
0.43 |
|
PPGVPSRRPP |
6.87
|
-10.61 |
-3.34 |
| Q07666 |
PPPVPRGRGV |
6.10
|
-9.21 |
-1.94 |
|
VPPPPTVRGA |
6.76
|
-10.48 |
-3.21 |
|
QPPPLLPPSA |
7.13
|
-9.81 |
-2.54 |
| Q9C0H9 |
FRLPPSSPQK |
6.58
|
-10.74 |
-3.47 |
|
PRSPGGRRGD |
6.60
|
-7.05 |
0.22 |
|
SPRSPGGRRG |
6.75
|
-8.81 |
-1.54 |
| P55196 |
LCRPPLPRDY |
5.00
|
-10.01 |
-2.74 |
|
LPAPLKPRPP |
5.36
|
-10.72 |
-3.45 |
|
RPPPCQPRPA |
5.57
|
-8.97 |
-1.70 |
| P00519 |
KPSQPGEGLK |
6.05
|
-7.83 |
-0.56 |
|
PLLPRKERGP |
6.27
|
-9.92 |
-2.65 |
|
KPVLPATPKP |
7.08
|
-10.47 |
-3.20 |
| Q9H5V8 |
NTEMPRQPKK |
7.65
|
-9.76 |
-2.49 |
|
EPPPRSPPES |
8.62
|
-9.18 |
-1.91 |
|
EEPPPRSPPE |
8.84
|
-8.19 |
-0.92 |
| Q13444 |
LPADPQGRCP |
6.05
|
-10.61 |
-3.34 |
|
KPPPPRKPLP |
6.32
|
-13.26 |
-5.99 |
|
RKPLPADPQG |
7.14
|
-10.45 |
-3.18 |
| Q06124 |
SPLPPCTPTP |
7.75
|
-10.21 |
-2.94 |
|
PPCTPTPPCA |
9.22
|
-8.04 |
-0.77 |
|
HDGDPNEPVS |
9.38
|
-7.16 |
0.11 |
| Q9Y5K6 |
RPKMPGRRLP |
2.01
|
-12.94 |
-5.67 |
|
KPSKPAAPQV |
5.92
|
-10.01 |
-2.74 |
|
QVPPKKPTPP |
6.86
|
-10.21 |
-2.94 |
| P56945 |
QPLAPGRTGG |
5.89
|
-9.13 |
-1.86 |
|
LPSPPKFTSQ |
6.31
|
-10.01 |
-2.74 |
|
TPAQPLAPGR |
7.18
|
-9.10 |
-1.83 |
| P06241 |
DPTPQHYPSF |
8.68
|
-8.88 |
-1.61 |
|
PTPQHYPSFG |
11.55
|
-3.97 |
3.30 |
|
PQHYPSFGVT |
12.05
|
-4.17 |
3.10 |
| P21860 |
RHSPPHPPRP |
7.27
|
-11.30 |
-4.03 |
|
HPVPIMPTAG |
7.38
|
-8.61 |
-1.34 |
|
RESGPGIAPG |
7.53
|
-7.98 |
-0.71 |
|
