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Matrix information:
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ADAN-name: 1SHD2.PDB
Scoring matrix: 1SHD2_mat
Uniprot code: P12931
Genome source: Homo sapiens
Wild-type ligand: yEEI
Foldx wt ligand score: 2.85
Foldx random average score for Homo sapiens: 10.667 Available information for P12931 in MINT (Nov 2008):
Nš of interacting proteins: 50
Proteins belonging to other specie: 11
Nš of interactions described: 106
Interactions with other species: 20
Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 1
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48060
Total fragments: 22392320
Proteins after random average filtering: 48056
Total fragments: 13483095
Proteins after disorder filtering: 38465
Total fragments: 1922655
Proteins after pattern filtering: 19995
Total fragments: 110165
Proteins after MINT filtering: 25
Total fragments: 257
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
yEEI |
2.85
|
-9.80 |
0.00 |
| Best peptides |
yEsM |
0.00
|
-9.01 |
0.79 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P49023 |
LYGV |
7.35
|
-3.92 |
5.88 |
|
YQEI |
7.68
|
-5.70 |
4.10 |
|
PLYG |
7.69
|
-3.31 |
6.49 |
| Q8WUM4 |
YCQM |
7.29
|
-4.45 |
5.35 |
|
QYNM |
8.12
|
-4.19 |
5.61 |
|
MPYP |
8.33
|
-3.00 |
6.80 |
| Q16832 |
YDPM |
5.75
|
-5.68 |
4.12 |
|
YDRI |
7.78
|
-4.10 |
5.70 |
|
PYDI |
7.88
|
-4.49 |
5.31 |
| P15941 |
YEKV |
7.08
|
-4.54 |
5.26 |
|
YHPM |
7.53
|
-4.52 |
5.28 |
|
SEYP |
7.75
|
-3.50 |
6.30 |
| P09848 |
YDTI |
7.51
|
-4.12 |
5.68 |
|
LGYG |
9.05
|
-1.82 |
7.98 |
|
PSYD |
9.15
|
-5.14 |
4.66 |
| P05106 |
YMYI |
7.03
|
-4.34 |
5.46 |
|
YISP |
7.90
|
-5.18 |
4.62 |
|
SPYM |
8.38
|
-2.76 |
7.04 |
| P00533 |
TYQM |
7.33
|
-4.76 |
5.04 |
|
MLYN |
7.39
|
-4.06 |
5.74 |
|
YQDP |
7.48
|
-5.39 |
4.41 |
| P22681 |
TEYM |
5.55
|
-5.35 |
4.45 |
|
YDDD |
6.40
|
-7.42 |
2.38 |
|
YMTP |
7.27
|
-4.46 |
5.34 |
| Q05655 |
YGKI |
9.88
|
-1.66 |
8.14 |
|
GTYG |
10.43
|
-0.56 |
9.24 |
| P03372 |
FYRP |
7.74
|
-4.48 |
5.32 |
|
PYGP |
8.36
|
-3.49 |
6.31 |
|
LPYG |
8.54
|
-2.43 |
7.37 |
| Q8TBB1 |
PAYV |
9.28
|
-2.47 |
7.33 |
|
YVSS |
9.39
|
-1.52 |
8.28 |
|
AYVS |
9.91
|
-1.23 |
8.57 |
| P25092 |
TYPV |
8.67
|
-3.32 |
6.48 |
|
YPVD |
9.10
|
-5.50 |
4.30 |
| Q05397 |
YQPV |
8.10
|
-3.77 |
6.03 |
|
FYPS |
8.36
|
-2.92 |
6.88 |
|
IYQP |
8.75
|
-3.60 |
6.20 |
| Q07666 |
EYYD |
6.75
|
-6.82 |
2.98 |
|
YDYG |
7.38
|
-3.79 |
6.01 |
|
YGQD |
9.81
|
-4.45 |
5.35 |
| Q9C0H9 |
LYGD |
6.73
|
-6.96 |
2.84 |
|
PLYG |
7.69
|
-3.31 |
6.49 |
|
LYKA |
7.83
|
-2.92 |
6.88 |
| P55196 |
YEPP |
6.97
|
-5.11 |
4.69 |
|
DYEP |
7.47
|
-5.90 |
3.90 |
|
ELYN |
7.64
|
-3.76 |
6.04 |
| P00519 |
VYGV |
8.48
|
-3.30 |
6.50 |
|
TVYG |
8.61
|
-2.16 |
7.64 |
|
YPAP |
9.47
|
-2.66 |
7.14 |
| O15455 |
YLCN |
8.43
|
-3.17 |
6.63 |
|
SHYL |
10.03
|
-1.91 |
7.89 |
|
HYLC |
10.09
|
-2.41 |
7.39 |
| Q9H5V8 |
YNGN |
9.08
|
-3.69 |
6.11 |
|
IYNG |
9.41
|
-3.30 |
6.50 |
|
GIYN |
9.70
|
-2.07 |
7.73 |
| Q13444 |
YVSC |
8.53
|
-3.66 |
6.14 |
|
SYVS |
10.25
|
-1.03 |
8.77 |
|
YCEE |
10.37
|
-1.86 |
7.94 |
| Q9Y5K6 |
TVYP |
8.55
|
-3.08 |
6.72 |
|
CYSP |
8.78
|
-3.19 |
6.61 |
|
SVYL |
8.96
|
-2.58 |
7.22 |
| P56945 |
DLYD |
6.42
|
-7.23 |
2.57 |
|
DIYD |
6.63
|
-6.39 |
3.41 |
|
EVYD |
6.89
|
-7.76 |
2.04 |
| P07550 |
AYGN |
9.57
|
-2.35 |
7.45 |
|
GYSS |
10.50
|
-0.66 |
9.14 |
| P06241 |
YRYG |
8.54
|
-2.47 |
7.33 |
|
YGTD |
9.35
|
-5.50 |
4.30 |
|
PNYN |
9.39
|
-2.52 |
7.28 |
| P21860 |
YEYM |
5.04
|
-6.03 |
3.77 |
|
YMPM |
5.48
|
-5.79 |
4.01 |
|
YAAM |
7.36
|
-4.21 |
5.59 |
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