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Matrix information:
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ADAN-name: 1LCK3.PDB
Scoring matrix: 1LCK3_mat
Uniprot code: P06239
Genome source: Homo sapiens
Wild-type ligand: EGQyQPQPA
Foldx wt ligand score: 6.17
Foldx random average score for Homo sapiens: 13.474 Available information for P06239 in MINT (Nov 2008):
Nš of interacting proteins: 20
Proteins belonging to other specie: 3
Nš of interactions described: 50
Interactions with other species: 22
Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 7698
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 40363
Total fragments: 18268483
Proteins after random average filtering: 40350
Total fragments: 11595611
Proteins after disorder filtering: 30468
Total fragments: 865377
Proteins after pattern filtering: 14851
Total fragments: 87494
Proteins after MINT filtering: 9
Total fragments: 50
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
EGQyQPQPA |
6.17
|
-4.86 |
0.00 |
| Best peptides |
sGsyLsMIy |
0.00
|
-7.14 |
-2.28 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P20963 |
KGHDGLYQG |
10.26
|
-0.87 |
3.99 |
| P04150 |
NGYSSPSMR |
11.80
|
-0.66 |
4.20 |
|
YSSPSMRPD |
12.61
|
-1.66 |
3.20 |
| P27986 |
YNETTGERG |
11.50
|
-0.23 |
4.63 |
|
GYNETTGER |
13.28
|
-2.22 |
2.64 |
| P22681 |
GEEDTEYMT |
8.87
|
-4.73 |
0.13 |
|
PNYDDDDDE |
10.78
|
-4.73 |
0.13 |
|
ENEDDGYDV |
10.81
|
-4.88 |
-0.02 |
| Q13283 |
SSYVHGGLD |
11.38
|
-2.31 |
2.55 |
|
NSSYVHGGL |
12.54
|
-1.29 |
3.57 |
| Q13444 |
RHCYCEEGW |
12.48
|
0.77 |
5.63 |
|
RNPSGSYVS |
13.03
|
1.80 |
6.66 |
|
HCYCEEGWA |
13.36
|
0.82 |
5.68 |
| Q13094 |
EEDDYESPN |
10.00
|
-4.87 |
-0.01 |
|
DDGDYESPN |
10.25
|
-6.21 |
-1.35 |
|
DADYEPPPS |
10.26
|
-3.42 |
1.44 |
| Q12959 |
DGYAPPDIT |
11.21
|
-4.56 |
0.30 |
|
NDGYAPPDI |
12.70
|
-1.92 |
2.94 |
|
MNDGYAPPD |
12.94
|
-2.18 |
2.68 |
| P43403 |
SDGYTPEPA |
8.98
|
-3.75 |
1.11 |
|
DTSVYESPY |
10.59
|
-1.27 |
3.59 |
|
LNSDGYTPE |
10.99
|
-2.76 |
2.10 |
|
