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Matrix information:
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ADAN-name: 1LCJ2.PDB
Scoring matrix: 1LCJ2_mat
Uniprot code: P06239
Genome source: Homo sapiens
Wild-type ligand: EPQyEEIPIYL
Foldx wt ligand score: 6.16
Foldx random average score for Homo sapiens: 17.472 Available information for P06239 in MINT (Nov 2008):
Nš of interacting proteins: 20
Proteins belonging to other specie: 3
Nš of interactions described: 50
Interactions with other species: 22
Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 7698
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 40363
Total fragments: 18187775
Proteins after random average filtering: 40331
Total fragments: 9284904
Proteins after disorder filtering: 28355
Total fragments: 586353
Proteins after pattern filtering: 13929
Total fragments: 87623
Proteins after MINT filtering: 8
Total fragments: 77
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
EPQyEEIPIYL |
6.16
|
-16.65 |
0.00 |
| Best peptides |
yssyDyMPyDy |
0.00
|
-18.04 |
-1.39 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P04150 |
GYSSPSMRPDV |
16.59
|
-3.70 |
12.95 |
|
SNGYSSPSMRP |
17.29
|
-4.69 |
11.96 |
| P27986 |
GYNETTGERGD |
17.18
|
-3.17 |
13.48 |
| P22681 |
EEDTEYMTPSS |
12.98
|
-8.67 |
7.98 |
|
DDGYDVPKPPV |
13.82
|
-9.84 |
6.81 |
|
SENEDDGYDVP |
13.98
|
-6.18 |
10.47 |
| Q13444 |
GVCDSNRHCYC |
14.99
|
-4.12 |
12.53 |
|
YCEEGWAPPDC |
16.06
|
-3.58 |
13.07 |
|
RHCYCEEGWAP |
16.14
|
-4.05 |
12.60 |
| Q13094 |
EDDYESPNDDQ |
12.32
|
-10.91 |
5.74 |
|
DADYEPPPSND |
12.88
|
-9.68 |
6.97 |
|
FEEDDYESPND |
13.30
|
-8.08 |
8.57 |
| Q12959 |
NDGYAPPDITN |
15.37
|
-9.49 |
7.16 |
|
YMNDGYAPPDI |
15.48
|
-4.21 |
12.44 |
|
TDSLETPTYVN |
15.67
|
-6.17 |
10.48 |
| P43405 |
SYSFPKPGHRK |
16.13
|
-4.72 |
11.93 |
| P43403 |
PMPMDTSVYES |
14.91
|
-5.95 |
10.70 |
|
MPMDTSVYESP |
15.40
|
-4.16 |
12.49 |
|
YTPEPARITSP |
16.10
|
-2.24 |
14.41 |
|
