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Matrix information:
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ADAN-name: 1HCT2.PDB
Scoring matrix: 1HCT2_mat
Uniprot code: P12931
Genome source: Homo sapiens
Wild-type ligand: yEEIE
Foldx wt ligand score: 6.89
Foldx random average score for Homo sapiens: 7.134 Available information for P12931 in MINT (Nov 2008):
Nš of interacting proteins: 50
Proteins belonging to other specie: 11
Nš of interactions described: 106
Interactions with other species: 20
Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 1
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48060
Total fragments: 22344260
Proteins after random average filtering: 48056
Total fragments: 11681904
Proteins after disorder filtering: 38293
Total fragments: 1719322
Proteins after pattern filtering: 15826
Total fragments: 45762
Proteins after MINT filtering: 22
Total fragments: 92
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
yEEIE |
6.89
|
-3.87 |
0.00 |
| Best peptides |
DMDGs |
0.00
|
1.81 |
5.68 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| Q8TBB1 |
AYVSS |
6.92
|
-0.06 |
3.81 |
| Q8WUM4 |
GYPGY |
4.82
|
-0.82 |
3.05 |
|
TYPGY |
5.01
|
0.49 |
4.36 |
|
PYPPV |
5.43
|
-2.36 |
1.51 |
| Q16832 |
PYDIF |
5.20
|
-2.82 |
1.05 |
|
TYDPM |
5.39
|
-0.67 |
3.20 |
| P15941 |
TYHPM |
6.12
|
-0.31 |
3.56 |
|
SEYPT |
6.17
|
0.42 |
4.29 |
|
YVPPS |
6.32
|
-1.94 |
1.93 |
| P09848 |
LGYGS |
5.66
|
0.73 |
4.60 |
|
AGYGT |
5.81
|
1.01 |
4.88 |
|
YGSGE |
6.36
|
0.74 |
4.61 |
| P05106 |
TYRGT |
5.12
|
0.33 |
4.20 |
|
GSYGD |
5.37
|
0.97 |
4.84 |
|
YCNCT |
6.73
|
-0.77 |
3.10 |
| P00533 |
LYNPT |
5.87
|
-0.89 |
2.98 |
|
TYGCT |
5.93
|
-0.03 |
3.84 |
|
CTYGC |
5.94
|
0.44 |
4.31 |
| P22681 |
YMTPS |
5.37
|
-1.65 |
2.22 |
|
YLFPD |
5.39
|
-0.63 |
3.24 |
|
YSVGA |
6.34
|
0.60 |
4.47 |
| Q05655 |
GTYGK |
5.80
|
0.86 |
4.73 |
| P03372 |
PYGPG |
5.13
|
-1.08 |
2.79 |
|
FYRPN |
6.28
|
-0.84 |
3.03 |
|
YGPGS |
6.52
|
0.78 |
4.65 |
| P49023 |
PLYGV |
3.68
|
-1.58 |
2.29 |
|
PVYGS |
3.93
|
-1.16 |
2.71 |
|
VYGSS |
6.93
|
1.04 |
4.91 |
| Q05397 |
GYPGS |
4.80
|
-0.82 |
3.05 |
|
IYQPV |
5.67
|
-0.55 |
3.32 |
|
PGYPS |
5.96
|
-0.25 |
3.62 |
| Q9C0H9 |
PLYGD |
3.45
|
-1.82 |
2.05 |
|
DGYGF |
4.36
|
-0.76 |
3.11 |
|
AYPGA |
5.00
|
-1.27 |
2.60 |
| P55196 |
EAYPI |
5.52
|
0.00 |
3.87 |
|
HYAGD |
5.59
|
0.98 |
4.85 |
|
SGYGS |
6.03
|
1.08 |
4.95 |
| P00519 |
TVYGV |
4.74
|
-0.21 |
3.66 |
| O15455 |
HYHGF |
5.95
|
0.96 |
4.83 |
| Q9H5V8 |
IYNGN |
4.74
|
-0.30 |
3.57 |
| Q13444 |
YVSCT |
6.32
|
-1.10 |
2.77 |
|
HCYCE |
6.55
|
1.45 |
5.32 |
| Q9Y5K6 |
TVYPK |
5.58
|
-1.15 |
2.72 |
|
CYSPK |
5.94
|
-0.04 |
3.83 |
|
SVYLS |
6.37
|
-1.80 |
2.07 |
| P56945 |
SQYGQ |
5.48
|
-0.01 |
3.86 |
|
TYQPQ |
5.85
|
-1.35 |
2.52 |
|
GVYAV |
5.95
|
-0.74 |
3.13 |
| P07550 |
YGNGY |
6.45
|
1.05 |
4.92 |
|
GYSSN |
6.90
|
-0.30 |
3.57 |
| P21860 |
DYAAM |
4.97
|
-2.37 |
1.50 |
|
GYMPM |
5.65
|
-1.92 |
1.95 |
|
YVMPD |
6.18
|
-2.00 |
1.87 |
|
