ADAN database

 

Scanning Information and Binding Energy of Known Targets

Matrix information:                                                    (Help)
ADAN-name: 1HCT2.PDB
Scoring matrix: 1HCT2_mat
Uniprot code: P12931
Genome source: Homo sapiens
Wild-type ligand: yEEIE
Foldx wt ligand score: 6.89
Foldx random average score for Homo sapiens: 7.134

Available information for P12931 in MINT (Nov 2008):
Nš of interacting proteins: 50
 Proteins belonging to other specie: 11
Nš of interactions described: 106
 Interactions with other species: 20

Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 1
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48060
 Total fragments: 22344260
Proteins after random average filtering: 48056
 Total fragments: 11681904
Proteins after disorder filtering: 38293
 Total fragments: 1719322
Proteins after pattern filtering: 15826
 Total fragments: 45762
Proteins after MINT filtering: 22
 Total fragments: 92


Prediction of know targets:

Ligand peptide Sequence Foldx score ΔGbinding ΔΔG
Reference wt

yEEIE

6.89

-3.87

0.00

Best peptides

DMDGs

0.00

1.81

5.68

         
Interactors      
Q8TBB1

AYVSS

6.92

-0.06

3.81

Q8WUM4

GYPGY

4.82

-0.82

3.05

TYPGY

5.01

0.49

4.36

PYPPV

5.43

-2.36

1.51

Q16832

PYDIF

5.20

-2.82

1.05

TYDPM

5.39

-0.67

3.20

P15941

TYHPM

6.12

-0.31

3.56

SEYPT

6.17

0.42

4.29

YVPPS

6.32

-1.94

1.93

P09848

LGYGS

5.66

0.73

4.60

AGYGT

5.81

1.01

4.88

YGSGE

6.36

0.74

4.61

P05106

TYRGT

5.12

0.33

4.20

GSYGD

5.37

0.97

4.84

YCNCT

6.73

-0.77

3.10

P00533

LYNPT

5.87

-0.89

2.98

TYGCT

5.93

-0.03

3.84

CTYGC

5.94

0.44

4.31

P22681

YMTPS

5.37

-1.65

2.22

YLFPD

5.39

-0.63

3.24

YSVGA

6.34

0.60

4.47

Q05655

GTYGK

5.80

0.86

4.73

P03372

PYGPG

5.13

-1.08

2.79

FYRPN

6.28

-0.84

3.03

YGPGS

6.52

0.78

4.65

P49023

PLYGV

3.68

-1.58

2.29

PVYGS

3.93

-1.16

2.71

VYGSS

6.93

1.04

4.91

Q05397

GYPGS

4.80

-0.82

3.05

IYQPV

5.67

-0.55

3.32

PGYPS

5.96

-0.25

3.62

Q9C0H9

PLYGD

3.45

-1.82

2.05

DGYGF

4.36

-0.76

3.11

AYPGA

5.00

-1.27

2.60

P55196

EAYPI

5.52

0.00

3.87

HYAGD

5.59

0.98

4.85

SGYGS

6.03

1.08

4.95

P00519

TVYGV

4.74

-0.21

3.66

O15455

HYHGF

5.95

0.96

4.83

Q9H5V8

IYNGN

4.74

-0.30

3.57

Q13444

YVSCT

6.32

-1.10

2.77

HCYCE

6.55

1.45

5.32

Q9Y5K6

TVYPK

5.58

-1.15

2.72

CYSPK

5.94

-0.04

3.83

SVYLS

6.37

-1.80

2.07

P56945

SQYGQ

5.48

-0.01

3.86

TYQPQ

5.85

-1.35

2.52

GVYAV

5.95

-0.74

3.13

P07550

YGNGY

6.45

1.05

4.92

GYSSN

6.90

-0.30

3.57

P21860

DYAAM

4.97

-2.37

1.50

GYMPM

5.65

-1.92

1.95

YVMPD

6.18

-2.00

1.87

 


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