ADAN database

 

Scanning Information and Binding Energy of Known Targets

Matrix information:                                                    (Help)
ADAN-name: 1H9O2.PDB
Scoring matrix: 1H9O2_mat
Uniprot code: P27986
Genome source: Homo sapiens
Wild-type ligand: yVPML
Foldx wt ligand score: 3.75
Foldx random average score for Homo sapiens: 13.485

Available information for P27986 in MINT (Nov 2008):
Nš of interacting proteins: 27
 Proteins belonging to other specie: 5
Nš of interactions described: 83
 Interactions with other species: 11

Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 1
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48060
 Total fragments: 22344072
Proteins after random average filtering: 48054
 Total fragments: 10858522
Proteins after disorder filtering: 37321
 Total fragments: 786083
Proteins after pattern filtering: 18289
 Total fragments: 72695
Proteins after MINT filtering: 14
 Total fragments: 125


Prediction of know targets:

Ligand peptide Sequence Foldx score ΔGbinding ΔΔG
Reference wt

yVPML

3.75

-12.91

0.00

Best peptides

yEWMN

0.00

-11.08

1.83

         
Interactors      
P00533

LMLYN

8.34

-4.31

8.60

MLYNP

10.78

-5.08

7.83

TYQMD

11.25

-7.10

5.81

O15455

YLCNT

12.04

-4.94

7.97

P22681

TEYMT

8.54

-6.94

5.97

DDGYD

11.62

-1.28

11.63

YLFPD

12.37

-4.98

7.93

Q07666

PETYE

10.70

-6.16

6.75

SEYYD

10.76

-4.59

8.32

YYDYG

11.85

-3.52

9.39

P35568

YMMMS

7.26

-9.71

3.20

YMPMS

7.56

-9.79

3.12

YMNMS

7.88

-8.54

4.37

P42336

AMYVY

10.36

-6.54

6.37

MYVYP

11.87

-2.23

10.68

YVYPP

13.31

-2.83

10.08

Q9UQC2

YVPMN

6.98

-10.71

2.20

YVPMQ

7.38

-10.06

2.85

YIPMS

8.36

-9.04

3.87

P29353

HQYYN

11.20

-5.80

7.11

YNDFP

11.63

-6.75

6.16

Q9Y5K6

SVYLS

10.32

-6.11

6.80

YLSTP

11.22

-6.63

6.28

DTCYS

12.59

-0.45

12.46

P43405

YDVVN

9.97

-6.23

6.68

SYSFP

13.05

-0.98

11.93

P04626

PEYLT

9.08

-6.54

6.37

PEYVN

9.30

-6.12

6.79

NLYYW

10.50

-2.01

10.90

P21860

YEYMN

5.48

-10.71

2.20

YMPMN

5.89

-11.36

1.55

YMNRQ

9.23

-9.52

3.39

P06239

YEGSN

10.41

-4.78

8.13

LVTYE

11.33

-6.16

6.75

VTYEG

12.16

-3.90

9.01

Q13480

YVPMN

6.98

-10.71

2.20

LYVFN

10.08

-5.02

7.89

EENYV

10.50

-6.10

6.81

 


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