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Matrix information:
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ADAN-name: 1D4W2.PDB
Scoring matrix: 1D4W2_mat
Uniprot code: O60880
Genome source: Homo sapiens
Wild-type ligand: SLTIyAQVQK
Foldx wt ligand score: 6.98
Foldx random average score for Homo sapiens: 19.958 Available information for O60880 in MINT (Nov 2008):
Nš of interacting proteins: 16
Proteins belonging to other specie: 2
Nš of interactions described: 24
Interactions with other species: 2
Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 7744
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 40317
Total fragments: 18210904
Proteins after random average filtering: 40287
Total fragments: 10273489
Proteins after disorder filtering: 27805
Total fragments: 393732
Proteins after pattern filtering: 12762
Total fragments: 58037
Proteins after MINT filtering: 8
Total fragments: 69
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
SLTIyAQVQK |
6.98
|
-23.60 |
0.00 |
| Best peptides |
yLVIyMRVWA |
0.00
|
-23.39 |
0.21 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P00533 |
PLMLYNPTTY |
14.77
|
-15.46 |
8.14 |
|
AGSVQNPVYH |
15.47
|
-10.28 |
13.32 |
|
SLDNPDYQQD |
15.53
|
-13.50 |
10.10 |
| O15117 |
QLDMGDEVYD |
9.82
|
-18.71 |
4.89 |
|
DDDIYDGIEE |
14.01
|
-16.56 |
7.04 |
|
DEVYDDVDTS |
15.26
|
-14.61 |
8.99 |
| Q9BZW8 |
FPGGGSTIYS |
19.75
|
-9.55 |
14.05 |
| Q14155 |
YHTLPHPSHH |
17.76
|
-12.17 |
11.43 |
|
PLTPAYHTLP |
18.49
|
-12.21 |
11.39 |
| P21860 |
DEDYEYMNRQ |
13.75
|
-15.50 |
8.10 |
|
DYEYMNRQRD |
14.56
|
-18.06 |
5.54 |
|
EEDVNGYVMP |
16.14
|
-16.58 |
7.02 |
| P06239 |
PLVTYEGSNP |
19.06
|
-13.84 |
9.76 |
| Q16288 |
YNNGNYTLIA |
16.76
|
-14.04 |
9.56 |
|
HYNNGNYTLI |
17.23
|
-12.77 |
10.83 |
|
KPTHYNNGNY |
18.17
|
-12.34 |
11.26 |
| P06241 |
VTSIPNYNNF |
16.68
|
-15.38 |
8.22 |
|
FGVTSIPNYN |
17.67
|
-10.00 |
13.60 |
|
NYNNFHAAGG |
17.89
|
-13.66 |
9.94 |
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