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Matrix information:
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ADAN-name: 1CWE2.PDB
Scoring matrix: 1CWE2_mat
Uniprot code: P06239
Genome source: Homo sapiens
Wild-type ligand: QyEEIP
Foldx wt ligand score: 3.56
Foldx random average score for Homo sapiens: 11.268 Available information for P06239 in MINT (Nov 2008):
Nš of interacting proteins: 20
Proteins belonging to other specie: 3
Nš of interactions described: 50
Interactions with other species: 22
Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 7698
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 40363
Total fragments: 18389560
Proteins after random average filtering: 40356
Total fragments: 9775965
Proteins after disorder filtering: 31124
Total fragments: 952823
Proteins after pattern filtering: 14620
Total fragments: 68232
Proteins after MINT filtering: 10
Total fragments: 44
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
QyEEIP |
3.56
|
-10.70 |
0.00 |
| Best peptides |
DyDyMG |
0.00
|
-9.36 |
1.34 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P20963 |
DGLYQG |
8.04
|
-2.40 |
8.30 |
| P04150 |
GYSSPS |
10.27
|
0.11 |
10.81 |
| P27986 |
GYNETT |
10.02
|
-0.28 |
10.42 |
| P22681 |
DTEYMT |
6.14
|
-5.57 |
5.13 |
|
EYMTPS |
7.31
|
-3.63 |
7.07 |
|
GYDVPK |
7.46
|
-2.55 |
8.15 |
| Q13283 |
SYVHGG |
9.99
|
-2.25 |
8.45 |
|
SSYVHG |
11.12
|
0.49 |
11.19 |
| Q13444 |
YCEEGW |
9.23
|
-1.80 |
8.90 |
|
CYCEEG |
9.35
|
-0.47 |
10.23 |
|
SYVSCT |
10.42
|
-2.01 |
8.69 |
| Q13094 |
EDDYES |
6.00
|
-4.82 |
5.88 |
|
DYEPPP |
6.51
|
-5.51 |
5.19 |
|
DYESPN |
6.92
|
-3.30 |
7.40 |
| Q12959 |
NDGYAP |
8.64
|
-1.93 |
8.77 |
|
DGYAPP |
9.23
|
-1.81 |
8.89 |
|
YMNDGY |
9.26
|
-1.96 |
8.74 |
| P43405 |
SYSFPK |
10.86
|
-1.32 |
9.38 |
| P43403 |
VYESPY |
8.78
|
-4.58 |
6.12 |
|
EFYSRD |
8.85
|
-2.33 |
8.37 |
|
DGYTPE |
9.69
|
-1.31 |
9.39 |
|
