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Matrix information:
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ADAN-name: 1CSZ2.PDB
Scoring matrix: 1CSZ2_mat
Uniprot code: P43405
Genome source: Homo sapiens
Wild-type ligand: TyETL
Foldx wt ligand score: 15.65
Foldx random average score for Homo sapiens: 16.816 Available information for P43405 in MINT (Nov 2008):
Nš of interacting proteins: 12
Proteins belonging to other specie: 1
Nš of interactions described: 40
Interactions with other species: 1
Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 1
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48060
Total fragments: 22344161
Proteins after random average filtering: 48053
Total fragments: 13695979
Proteins after disorder filtering: 38737
Total fragments: 2251167
Proteins after pattern filtering: 20202
Total fragments: 137827
Proteins after MINT filtering: 10
Total fragments: 100
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
TyETL |
15.65
|
4.98 |
0.00 |
| Best peptides |
sMARG |
0.00
|
12.48 |
7.50 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P00533 |
YGCTG |
2.95
|
5.07 |
0.09 |
|
NCTYG |
5.56
|
4.93 |
-0.05 |
|
KYSFG |
6.95
|
4.79 |
-0.19 |
| P27986 |
YNETT |
10.24
|
6.83 |
1.85 |
|
GYNET |
12.09
|
7.85 |
2.87 |
|
NGYNE |
16.15
|
12.53 |
7.55 |
| P22681 |
PYSVG |
3.43
|
3.39 |
-1.59 |
|
YSVGA |
6.07
|
5.11 |
0.13 |
|
GYDVP |
8.90
|
5.43 |
0.45 |
| P04626 |
RYTFG |
7.79
|
5.13 |
0.15 |
|
YSEDP |
8.40
|
3.79 |
-1.19 |
|
LQRYS |
9.29
|
5.97 |
0.99 |
| P21860 |
YAAMG |
1.59
|
4.19 |
-0.79 |
|
GGDYA |
5.56
|
4.77 |
-0.21 |
|
KYQYG |
6.07
|
4.32 |
-0.66 |
| P06239 |
VTYEG |
5.23
|
6.06 |
1.08 |
|
TYEGS |
9.91
|
4.89 |
-0.09 |
|
YPIVP |
13.21
|
7.69 |
2.71 |
| P09769 |
FRSYG |
4.87
|
5.87 |
0.89 |
|
SYGAA |
5.10
|
5.51 |
0.53 |
|
ADHYG |
5.70
|
5.55 |
0.57 |
| Q8WV28 |
SYEPP |
8.51
|
5.95 |
0.97 |
|
RRDYA |
9.72
|
4.27 |
-0.71 |
|
DYENP |
10.69
|
3.60 |
-1.38 |
| O00459 |
SHYRP |
11.25
|
7.92 |
2.94 |
|
HYRPE |
13.56
|
8.42 |
3.44 |
| Q15303 |
GRCYG |
3.68
|
5.75 |
0.77 |
|
YPWTG |
5.32
|
4.24 |
-0.74 |
|
GYMTP |
7.85
|
5.43 |
0.45 |
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