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Matrix information:
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ADAN-name: 2SRC3.PDB
Scoring matrix: 2SRC3_mat
Uniprot code: P12931
Genome source: Homo sapiens
Wild-type ligand: PQyQPGENL
Foldx wt ligand score: 7.07
Foldx random average score for Homo sapiens: 10.617 Available information for P12931 in MINT (Nov 2008):
Nš of interacting proteins: 50
Proteins belonging to other specie: 11
Nš of interactions described: 106
Interactions with other species: 20
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22152566
Proteins after random average filtering: 48046
Total fragments: 11728581
Proteins after disorder filtering: 35566
Total fragments: 999244
Proteins after pattern filtering: 17894
Total fragments: 110075
Proteins after MINT filtering: 25
Total fragments: 221
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
PQyQPGENL |
7.07
|
-4.91 |
0.00 |
| Best peptides |
GWIMsGMMY |
0.00
|
-2.66 |
2.25 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P49023 |
SSPVYGSSA |
7.21
|
-0.38 |
4.53 |
|
LSPLYGVPE |
8.30
|
1.31 |
6.22 |
|
PGALSPLYG |
8.60
|
-2.82 |
2.09 |
| Q8WUM4 |
QAPYPGPQQ |
8.09
|
0.00 |
4.91 |
|
QMPMPMGYN |
8.54
|
-1.59 |
3.32 |
|
PVYHQSPGQ |
8.55
|
-0.08 |
4.83 |
| P21860 |
GGDYAAMGA |
6.61
|
-2.53 |
2.38 |
|
EEDVNGYVM |
7.18
|
-4.31 |
0.60 |
|
PGGDYAAMG |
7.72
|
-0.35 |
4.56 |
| P15941 |
YEKVSAGNG |
8.25
|
-0.79 |
4.12 |
|
PTYHTHGRY |
8.89
|
-1.35 |
3.56 |
|
PYEKVSAGN |
9.21
|
-1.15 |
3.76 |
| P09848 |
NTCIPSYDT |
8.17
|
-2.17 |
2.74 |
|
PSGYSQRFG |
8.44
|
0.09 |
5.00 |
|
PSYDTIGGF |
9.00
|
0.82 |
5.73 |
| P05106 |
VCIQPGSYG |
7.59
|
-1.14 |
3.77 |
|
PYMYISPPE |
8.56
|
-0.67 |
4.24 |
|
CDSDWTGYY |
8.74
|
-0.72 |
4.19 |
| P00533 |
PTTYQMDVN |
7.72
|
-2.25 |
2.66 |
|
PNCTYGCTG |
8.03
|
-0.44 |
4.47 |
|
DNPDYQQDF |
8.56
|
0.65 |
5.56 |
| P12814 |
MDHYDSQQT |
8.27
|
0.43 |
5.34 |
| P22681 |
PYSVGAESR |
7.30
|
-2.65 |
2.26 |
|
GEEDTEYMT |
8.80
|
-0.38 |
4.53 |
|
EDTEYMTPS |
8.98
|
2.09 |
7.00 |
| Q05655 |
MQDNSGTYG |
9.05
|
-0.77 |
4.14 |
|
SGTYGKIWE |
9.19
|
-1.17 |
3.74 |
|
NSGTYGKIW |
9.55
|
2.11 |
7.02 |
| P03372 |
GLPYGPGSE |
9.66
|
0.35 |
5.26 |
|
PAFYRPNSD |
9.90
|
-1.46 |
3.45 |
|
YGPGSEAAA |
9.91
|
1.26 |
6.17 |
| Q8TBB1 |
PAYVSSAED |
8.30
|
-2.63 |
2.28 |
|
YVSSAEDGQ |
9.34
|
0.21 |
5.12 |
|
AYVSSAEDG |
9.46
|
-0.22 |
4.69 |
| P25092 |
TYPVDMSPT |
9.88
|
1.84 |
6.75 |
| Q05397 |
VSGYPGSHG |
8.27
|
0.70 |
5.61 |
|
NQHIYQPVG |
8.74
|
-0.85 |
4.06 |
|
GYPSPRSSE |
9.99
|
1.38 |
6.29 |
| Q07666 |
GDSEYYDYG |
7.84
|
-3.09 |
1.82 |
|
YYSQSQGDS |
9.24
|
0.31 |
5.22 |
|
QSQGDSEYY |
9.66
|
-0.65 |
4.26 |
| Q9C0H9 |
GGPLYGDGY |
3.03
|
-1.20 |
3.71 |
|
PFAYPGAGG |
6.51
|
-0.76 |
4.15 |
|
AYPGAGGLY |
7.44
|
0.68 |
5.59 |
| P55196 |
PWAEYSEPK |
6.74
|
-0.95 |
3.96 |
|
PVHYAGDFD |
6.87
|
-0.87 |
4.04 |
|
DGSGYGSTL |
8.14
|
0.80 |
5.71 |
| O15455 |
LSSHYLCNT |
9.91
|
0.71 |
5.62 |
|
YLCNTPPHY |
10.54
|
-0.41 |
4.50 |
| Q9H5V8 |
VGIYNGNIN |
6.06
|
-0.93 |
3.98 |
|
PESESEPYT |
6.93
|
-2.82 |
2.09 |
|
KGPAVGIYN |
7.59
|
1.15 |
6.06 |
| Q13444 |
RHCYCEEGW |
9.05
|
-0.45 |
4.46 |
|
CDSNRHCYC |
9.77
|
0.22 |
5.13 |
|
HCYCEEGWA |
10.00
|
-0.51 |
4.40 |
| Q9Y5K6 |
PSVYLSTPS |
8.89
|
0.09 |
5.00 |
|
GTVYPKRPE |
9.37
|
1.80 |
6.71 |
|
YSPKPSVYL |
9.54
|
0.14 |
5.05 |
| P56945 |
GVVDSGVYA |
7.62
|
-0.81 |
4.10 |
|
PDGQYENSE |
7.80
|
-0.45 |
4.46 |
|
RDPLLEVYD |
8.04
|
-1.38 |
3.53 |
| P07550 |
GNGYSSNGN |
7.33
|
0.65 |
5.56 |
|
GYSSNGNTG |
7.64
|
0.61 |
5.52 |
| P06241 |
PQHYPSFGV |
9.19
|
-0.08 |
4.83 |
|
HYPSFGVTS |
9.72
|
2.15 |
7.06 |
|
VTSIPNYNN |
9.75
|
-0.89 |
4.02 |
| Q16832 |
RYPLGMSGG |
8.80
|
-1.16 |
3.75 |
|
GNSNPYDIF |
9.21
|
-0.88 |
4.03 |
|
EQGSNSTYD |
10.09
|
1.15 |
6.06 |
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