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Matrix information:
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ADAN-name: 2IUI2.PDB
Scoring matrix: 2IUI2_mat
Uniprot code: P27986
Genome source: Homo sapiens
Wild-type ligand: SIDyVPMLDMK
Foldx wt ligand score: 4.27
Foldx random average score for Homo sapiens: 17.127 Available information for P27986 in MINT (Nov 2008):
Nš of interacting proteins: 27
Proteins belonging to other specie: 5
Nš of interactions described: 83
Interactions with other species: 11
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22056464
Proteins after random average filtering: 48030
Total fragments: 12437529
Proteins after disorder filtering: 33385
Total fragments: 549929
Proteins after pattern filtering: 16474
Total fragments: 86433
Proteins after MINT filtering: 14
Total fragments: 157
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
SIDyVPMLDMK |
4.27
|
-18.70 |
0.00 |
| Best peptides |
DyGyMWMMRLM |
0.00
|
-17.90 |
0.80 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P00533 |
CPPLMLYNPTT |
11.30
|
-8.25 |
10.45 |
|
PDYQQDFFPKE |
11.71
|
-12.16 |
6.54 |
|
TTYQMDVNPEG |
14.22
|
-9.76 |
8.94 |
| P62993 |
GQTGMFPRNYV |
16.18
|
-6.31 |
12.39 |
|
GMFPRNYVTPV |
17.08
|
-7.97 |
10.73 |
| P22681 |
ENEDDGYDVPK |
11.79
|
-8.43 |
10.27 |
|
GEEDTEYMTPS |
12.23
|
-7.95 |
10.75 |
|
EEDTEYMTPSS |
12.55
|
-11.77 |
6.93 |
| Q07666 |
SQGDSEYYDYG |
12.61
|
-7.43 |
11.27 |
|
QSQGDSEYYDY |
15.80
|
-4.73 |
13.97 |
| P35568 |
DDGYMPMSPGV |
7.71
|
-14.57 |
4.13 |
|
SGDYMPMSPKS |
8.77
|
-15.44 |
3.26 |
|
TGDYMNMSPVG |
9.47
|
-14.41 |
4.29 |
| P42336 |
YHGGEPLCDNV |
15.97
|
-8.81 |
9.89 |
| Q9UQC2 |
QSVYIPMSPGA |
10.22
|
-12.49 |
6.21 |
|
EDNYVPMNPGS |
10.39
|
-13.34 |
5.36 |
|
EENYVPMQNPV |
11.78
|
-13.05 |
5.65 |
| P29353 |
EPPDHQYYNDF |
14.11
|
-6.96 |
11.74 |
|
HQYYNDFPGKE |
15.23
|
-8.18 |
10.52 |
| Q9Y5K6 |
SSGTVYPKRPE |
15.25
|
-7.60 |
11.10 |
|
PKPSVYLSTPS |
16.21
|
-8.16 |
10.54 |
|
LRSSGTVYPKR |
16.62
|
-6.59 |
12.11 |
| P43405 |
SYSFPKPGHRK |
16.39
|
-8.01 |
10.69 |
| O15455 |
YHGFPVRLFDT |
14.81
|
-8.80 |
9.90 |
|
SSHYLCNTPPH |
15.86
|
-8.84 |
9.86 |
|
LCNTPPHYHGF |
16.86
|
-3.30 |
15.40 |
| P04626 |
AFDNLYYWDQD |
11.31
|
-9.77 |
8.93 |
|
SPAFDNLYYWD |
11.42
|
-11.08 |
7.62 |
|
PAFDNLYYWDQ |
12.63
|
-7.29 |
11.41 |
| P21860 |
SSGYMPMNQGN |
9.05
|
-13.92 |
4.78 |
|
DEDYEYMNRQR |
9.07
|
-15.54 |
3.16 |
|
DYEYMNRQRDG |
10.29
|
-12.92 |
5.78 |
| Q13480 |
EENYVPMNPNL |
10.80
|
-13.72 |
4.98 |
|
HDSEENYVPMN |
12.66
|
-12.00 |
6.70 |
|
SDTDSSYCIPT |
13.42
|
-7.09 |
11.61 |
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