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Matrix information:
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ADAN-name: 2FO02.PDB
Scoring matrix: 2FO02_mat
Uniprot code: P00519
Genome source: Homo sapiens
Wild-type ligand: KRNKPTVYGVSPNYD
Foldx wt ligand score: 5.77
Foldx random average score for Homo sapiens: 16.736 Available information for P00519 in MINT (Nov 2008):
Nš of interacting proteins: 29
Proteins belonging to other specie: 2
Nš of interactions described: 54
Interactions with other species: 4
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 21864330
Proteins after random average filtering: 48017
Total fragments: 12712723
Proteins after disorder filtering: 32734
Total fragments: 1032469
Proteins after pattern filtering: 23898
Total fragments: 378981
Proteins after MINT filtering: 20
Total fragments: 1006
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
KRNKPTVYGVSPNYD |
5.77
|
-11.14 |
0.00 |
| Best peptides |
RPHRWRIPGKYADNE |
0.00
|
-11.36 |
-0.22 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P06400 |
IPHIPRSPYKFPSSP |
8.98
|
-9.41 |
1.73 |
|
PYKFPSSPLRIPGGN |
9.12
|
-8.48 |
2.66 |
|
GGNIYISPLKSPYKI |
9.95
|
-8.23 |
2.91 |
| P00533 |
GSVQNPVYHNQPLNP |
9.84
|
-8.63 |
2.51 |
|
NQPLNPAPSRDPHYQ |
10.92
|
-8.39 |
2.75 |
|
VPKRPAGSVQNPVYH |
12.23
|
-8.80 |
2.34 |
| O14746 |
PLPKRPRRGAAPEPE |
9.09
|
-7.29 |
3.85 |
|
SLPLPKRPRRGAAPE |
9.46
|
-8.85 |
2.29 |
|
PERTPVGQGSWAHPG |
9.58
|
-7.37 |
3.77 |
| O15399 |
PPPPPWAAGPLPRRR |
7.97
|
-8.50 |
2.64 |
|
EDESPPAPARWPRSD |
8.77
|
-9.09 |
2.05 |
|
PGEPPLLPGGAPLPA |
9.91
|
-9.14 |
2.00 |
| P22681 |
RRPLPCTPGDCPSRD |
6.68
|
-9.07 |
2.07 |
|
MEPRPDVPRLGSTFS |
8.70
|
-8.89 |
2.25 |
|
DKLPPVPSSRLGDSW |
9.64
|
-7.40 |
3.74 |
| P18031 |
PPPRPPKRILEPHNG |
9.59
|
-10.66 |
0.48 |
|
PRPPKRILEPHNGKC |
11.62
|
-8.10 |
3.04 |
|
EDLEPPPEHIPPPPR |
15.17
|
-8.60 |
2.54 |
| Q92558 |
PPPPPPMHGAGDAKP |
9.10
|
-9.59 |
1.55 |
|
NRPQSPATGRTPVFV |
10.09
|
-6.56 |
4.58 |
|
PPPPLPPPGIRPSSP |
10.42
|
-8.83 |
2.31 |
| O15162 |
PPPPAGHSGPGPAGF |
10.90
|
-6.79 |
4.35 |
|
AAGVPWMPAPQPPLN |
11.11
|
-9.77 |
1.37 |
|
FPVPNQPVYNQPVYN |
11.22
|
-7.92 |
3.22 |
| P12931 |
ASQTPSKPASADGHR |
11.11
|
-5.05 |
6.09 |
|
AFPASQTPSKPASAD |
12.34
|
-5.75 |
5.39 |
|
FPASQTPSKPASADG |
14.63
|
-2.80 |
8.34 |
| Q8IZP0 |
PSPPMSGRGTLGRNT |
10.11
|
-6.22 |
4.92 |
|
TPPPPPPPDDIPMFD |
10.23
|
-11.06 |
0.08 |
|
PTPSPPTIGPENISV |
10.99
|
-5.55 |
5.59 |
| Q13671 |
PPPVPVLPGAVPSQT |
9.04
|
-11.26 |
-0.12 |
|
EEGVPGSRGSPATSP |
9.83
|
-7.46 |
3.68 |
|
VPPPPVPVLPGAVPS |
11.83
|
-6.73 |
4.41 |
| P04626 |
PQPPSPREGPLPAAR |
9.76
|
-6.72 |
4.42 |
|
RSPLAPSEGAGSDVF |
9.91
|
-5.37 |
5.77 |
|
FFCPDPAPGAGGMVH |
10.17
|
-4.73 |
6.41 |
| P21860 |
PVPIMPTAGTTPDED |
8.03
|
-7.58 |
3.56 |
|
ESGPGIAPGPEPHGL |
9.47
|
-5.88 |
5.26 |
|
CPLHPVPIMPTAGTT |
11.97
|
-4.92 |
6.22 |
| P04637 |
AAPTPAAPAPAPSWP |
11.64
|
-5.53 |
5.61 |
|
WFTEDPGPDEAPRMP |
12.00
|
-8.42 |
2.72 |
|
PDEAPRMPEAAPPVA |
12.04
|
-11.37 |
-0.23 |
| O15350 |
MSPAPVIPSNTDYPG |
8.16
|
-9.51 |
1.63 |
|
TIPNRGGPGGGPDEW |
8.63
|
-6.63 |
4.51 |
|
RGGPGGGPDEWADFG |
9.74
|
-9.12 |
2.02 |
| P15941 |
PFSIPSHHSDTPTTL |
11.01
|
-10.21 |
0.93 |
|
AHGVTSAPDNRPALG |
11.41
|
-9.01 |
2.13 |
|
KSTPFSIPSHHSDTP |
11.44
|
-9.97 |
1.17 |
| Q9NYB9 |
SAPAPLVPATVPSST |
9.51
|
-8.99 |
2.15 |
|
SPTPPVVSSTPPTGH |
10.36
|
-9.88 |
1.26 |
|
PSPPMSGKGTLGRHS |
10.92
|
-5.21 |
5.93 |
| Q15303 |
FAPERSPRGELDEEG |
9.68
|
-6.55 |
4.59 |
|
EIGHSPPPAYTPMSG |
12.10
|
-7.18 |
3.96 |
|
ECHPCHPNCTQGCNG |
12.25
|
-2.90 |
8.24 |
| P78527 |
GVWMIPTSDPAANLH |
9.73
|
-6.13 |
5.01 |
|
APGVWMIPTSDPAAN |
11.00
|
-9.56 |
1.58 |
|
PGVWMIPTSDPAANL |
12.82
|
-6.81 |
4.33 |
| Q09472 |
IPGQPGMPQGQPGLQ |
7.71
|
-10.83 |
0.31 |
|
GLQPPTMPGQQGVHS |
8.34
|
-8.17 |
2.97 |
|
MSENASVPSLGPMPT |
8.80
|
-11.73 |
-0.59 |
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