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Matrix information:
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ADAN-name: 2CIA2.PDB
Scoring matrix: 2CIA2_mat
Uniprot code: O43639
Genome source: Homo sapiens
Wild-type ligand: HIyDEVAA
Foldx wt ligand score: 8.59
Foldx random average score for Homo sapiens: 23.056 Available information for O43639 in MINT (Nov 2008):
Nš of interacting proteins: 18
Proteins belonging to other specie: 0
Nš of interactions described: 25
Interactions with other species: 0
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22200620
Proteins after random average filtering: 48051
Total fragments: 12664615
Proteins after disorder filtering: 36696
Total fragments: 965764
Proteins after pattern filtering: 19166
Total fragments: 124570
Proteins after MINT filtering: 15
Total fragments: 270
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
HIyDEVAA |
8.59
|
-16.89 |
0.00 |
| Best peptides |
yDyyDIyG |
0.00
|
-24.04 |
-7.15 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P51116 |
YSLLDTSE |
16.62
|
-8.32 |
8.57 |
|
YNSSSISS |
18.35
|
-8.20 |
8.69 |
|
YSTDESSS |
19.42
|
-6.04 |
10.85 |
| Q5T6W5 |
RDYDDMSP |
14.78
|
-10.51 |
6.38 |
|
NFYDETYD |
16.73
|
-11.32 |
5.57 |
|
YDDMSPRR |
17.36
|
-6.68 |
10.21 |
| Q5ST11 |
GDYMEPEK |
18.92
|
-8.47 |
8.42 |
|
NTYAVPAL |
19.05
|
-8.90 |
7.99 |
|
YDGHTVGG |
19.10
|
-5.66 |
11.23 |
| Q5T5P2 |
RSYLPGSG |
18.86
|
-7.74 |
9.15 |
|
YKAQNGSS |
20.77
|
-4.85 |
12.04 |
|
YGGTRSMV |
22.04
|
-4.16 |
12.73 |
| Q8N684 |
DTYMKASA |
18.30
|
-9.50 |
7.39 |
|
YFNRPPSA |
18.71
|
-6.01 |
10.88 |
|
IHYQHLMP |
20.49
|
-8.32 |
8.57 |
| P54259 |
PFYVPLGA |
18.78
|
-10.12 |
6.77 |
|
PKYTQPSL |
19.49
|
-8.11 |
8.78 |
|
FPYSSSSS |
19.94
|
-4.61 |
12.28 |
| Q13191 |
DYDQLPSC |
18.30
|
-6.57 |
10.32 |
|
YNPDLTGL |
18.61
|
-7.23 |
9.66 |
|
DEYKIPSS |
18.75
|
-9.74 |
7.15 |
| Q9Y2W2 |
YPEDMDQD |
17.84
|
-6.95 |
9.94 |
|
EDDGYPED |
19.47
|
-5.36 |
11.53 |
|
TSEDDGYP |
19.90
|
-5.80 |
11.09 |
| P04626 |
ETDGYVAP |
17.80
|
-6.55 |
10.34 |
|
PAFDNLYY |
18.21
|
-10.16 |
6.73 |
|
YSEDPTVP |
18.22
|
-7.98 |
8.91 |
| Q16630 |
RDYMDTLP |
17.53
|
-9.11 |
7.78 |
|
EDRDYMDT |
19.63
|
-10.48 |
6.41 |
|
APEDRDYM |
20.08
|
-6.53 |
10.36 |
| Q6GU34 |
LDTLYTSS |
19.36
|
-7.33 |
9.56 |
|
TSLDTLYT |
19.75
|
-8.32 |
8.57 |
|
LYQIPPQP |
20.48
|
-6.56 |
10.33 |
| Q15303 |
ELDEEGYM |
17.86
|
-10.01 |
6.88 |
|
TSHDCIYY |
18.03
|
-8.49 |
8.40 |
|
EGYMTPMR |
18.04
|
-7.68 |
9.21 |
| Q15654 |
QCYQAPGG |
19.09
|
-7.04 |
9.85 |
|
LPSEQCYQ |
19.52
|
-6.52 |
10.37 |
|
GEYFGQCG |
20.01
|
-8.59 |
8.30 |
| Q13802 |
YSQNPVSD |
17.29
|
-8.33 |
8.56 |
|
YSMNRPAS |
17.84
|
-8.65 |
8.24 |
|
WYEGVMNG |
20.52
|
-5.39 |
11.50 |
| P21860 |
EDYEYMNR |
16.32
|
-11.09 |
5.80 |
|
YEYMNRQR |
17.68
|
-7.77 |
9.12 |
|
PDEDYEYM |
18.13
|
-8.13 |
8.76 |
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