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Matrix information:
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ADAN-name: 2CI92.PDB
Scoring matrix: 2CI92_mat
Uniprot code: P16333
Genome source: Homo sapiens
Wild-type ligand: HIyDEVAAD
Foldx wt ligand score: 8.36
Foldx random average score for Homo sapiens: 22.197 Available information for P16333 in MINT (Nov 2008):
Nš of interacting proteins: 28
Proteins belonging to other specie: 9
Nš of interactions described: 48
Interactions with other species: 16
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22152566
Proteins after random average filtering: 48044
Total fragments: 11909812
Proteins after disorder filtering: 34772
Total fragments: 642348
Proteins after pattern filtering: 17806
Total fragments: 100315
Proteins after MINT filtering: 11
Total fragments: 130
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
HIyDEVAAD |
8.36
|
-17.09 |
0.00 |
| Best peptides |
yDyyEIWyY |
0.00
|
-22.19 |
-5.10 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P00533 |
NPDYQQDFF |
17.06
|
-7.15 |
9.94 |
|
TYQMDVNPE |
17.20
|
-10.02 |
7.07 |
|
ISLDNPDYQ |
18.55
|
-8.48 |
8.61 |
| O43426 |
AGYSTARPT |
21.28
|
-6.54 |
10.55 |
| P22681 |
NYDDDDDER |
16.48
|
-6.35 |
10.74 |
|
GEEDTEYMT |
16.58
|
-7.74 |
9.35 |
|
PNYDDDDDE |
16.61
|
-12.55 |
4.54 |
| P49023 |
HTYQEIAVP |
17.75
|
-9.30 |
7.79 |
|
SYPTGNHTY |
20.60
|
-5.17 |
11.92 |
|
QSSSPVYGS |
20.86
|
-5.05 |
12.04 |
| Q13444 |
HCYCEEGWA |
18.78
|
-3.95 |
13.14 |
|
CYCEEGWAP |
20.41
|
-6.73 |
10.36 |
|
CDSNRHCYC |
21.81
|
-5.60 |
11.49 |
| Q13191 |
EYDVPPRLS |
18.44
|
-7.24 |
9.85 |
|
SDYDLLIPP |
19.08
|
-9.74 |
7.35 |
|
FYLYPDGRS |
19.25
|
-6.13 |
10.96 |
| P35968 |
SGYHSDDTD |
20.75
|
-4.88 |
12.21 |
|
SGYQSGYHS |
21.84
|
-5.80 |
11.29 |
| Q14155 |
APLTPAYHT |
21.44
|
-5.16 |
11.93 |
|
AYHTLPHPS |
21.56
|
-5.53 |
11.56 |
|
PAPLTPAYH |
22.07
|
-4.52 |
12.57 |
| P21860 |
PDEDYEYMN |
15.01
|
-8.99 |
8.10 |
|
EDYEYMNRQ |
15.51
|
-10.42 |
6.67 |
|
KYPDVQNEC |
17.25
|
-7.90 |
9.19 |
| P06241 |
PNYNNFHAA |
18.60
|
-6.84 |
10.25 |
|
TDPTPQHYP |
20.14
|
-7.22 |
9.87 |
|
LNQSSGYRY |
20.42
|
-4.64 |
12.45 |
| Q07912 |
PTYDPVSED |
15.82
|
-9.51 |
7.58 |
|
YDPVSEDQD |
17.41
|
-10.41 |
6.68 |
|
DRIDELYLG |
17.74
|
-11.83 |
5.26 |
|
