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Matrix information:
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ADAN-name: 2C0T3.PDB
Scoring matrix: 2C0T3_mat
Uniprot code: P08631
Genome source: Homo sapiens
Wild-type ligand: CMSSKPQKPWEKDA
Foldx wt ligand score: 8.14
Foldx random average score for Homo sapiens: 12.461 Available information for P08631 in MINT (Nov 2008):
Nš of interacting proteins: 16
Proteins belonging to other specie: 7
Nš of interactions described: 37
Interactions with other species: 17
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 21912354
Proteins after random average filtering: 48019
Total fragments: 10826788
Proteins after disorder filtering: 31815
Total fragments: 491656
Proteins after pattern filtering: 23355
Total fragments: 222152
Proteins after MINT filtering: 7
Total fragments: 168
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
CMSSKPQKPWEKDA |
8.14
|
-11.01 |
0.00 |
| Best peptides |
WRDDKPYRFYQMWE |
0.00
|
-16.24 |
-5.23 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| Q92556 |
IPDAPPPIPKEPSN |
6.85
|
-13.14 |
-2.13 |
| Q53H12 |
YTGPTERPPNEPEE |
10.85
|
-9.63 |
1.38 |
|
TGPTERPPNEPEET |
12.21
|
-7.76 |
3.25 |
| Q13177 |
KPPAPPVRMSSTIF |
9.71
|
-10.46 |
0.55 |
|
EKDGFPSGTPALNA |
9.73
|
-8.83 |
2.18 |
| O43516 |
ETPRLPQRNLSLSS |
6.80
|
-12.06 |
-1.05 |
|
ALDDKPPPPPPPVG |
7.53
|
-12.10 |
-1.09 |
|
PFSNRPPLPPTPSR |
7.58
|
-12.31 |
-1.30 |
| P42768 |
NEERRGGLPPLPLH |
7.92
|
-12.38 |
-1.37 |
|
RRGGLPPLPLHPGG |
8.28
|
-13.57 |
-2.56 |
|
NQLPRPPIVGGNKG |
9.23
|
-12.68 |
-1.67 |
| P21860 |
QSCPLHPVPIMPTA |
9.75
|
-10.40 |
0.61 |
|
PLHPVPIMPTAGTT |
9.90
|
-11.24 |
-0.23 |
|
LTPVTPLSPPGLEE |
10.36
|
-11.13 |
-0.12 |
| Q13444 |
PAKPPPPRKPLPAD |
7.22
|
-12.94 |
-1.93 |
|
PPPPRKPLPADPQG |
7.42
|
-12.47 |
-1.46 |
|
ERPGPPQRALLARG |
9.55
|
-10.89 |
0.12 |
|
