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Scanning Information, ROC parameters and
Binding Energy of Known Targets

Matrix information:                                                    (Help)
ADAN-name: 2BTP2.PDB
Scoring matrix: 2BTP2_mat
Uniprot code: P27348
Genome source: Homo sapiens
Wild-type ligand: RQRsAP
Foldx wt ligand score: 6.76
Foldx random average score for Homo sapiens: 11.741

Available information for P27348 in MINT (Nov 2008):
Nº of interacting proteins: 33
 Proteins belonging to other specie: 1
Nº of interactions described: 50
 Interactions with other species: 2

Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having weird amino acids: 22829
Total scanned proteins: 48061
 Total fragments: 22296734
Proteins after random average filtering: 48053
 Total fragments: 11913782
Proteins after disorder filtering: 37137
 Total fragments: 1088165
Proteins after pattern filtering: 3070
 Total fragments: 3659
Proteins after MINT filtering: 4
 Total fragments: 4

ROC parameters:
TPR= 0.121
FPR= 0.064
ACC= 0.936
SPC= 0.936
MCC= 0.006

Prediction of know targets:

Ligand peptide Sequence Foldx score ΔGbinding ΔΔG
Reference wt

RQRsAP

6.76

-11.36

0.00

Best peptides

yMMsyP

0.00

-11.32

0.04

         
Interactors      
P15056

RSSSAP

11.29

-6.29

5.07

P49815

RSMSGG

11.06

-6.20

5.16

P78314

RRMSDP

7.55

-10.51

0.85

Q6PKG0

RHSSNP

10.26

-8.53

2.83

 


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