ADAN database

 

Scanning Information and Binding Energy of Known Targets

Matrix information:                                                    (Help)
ADAN-name: 1UTI2.PDB
Scoring matrix: 1UTI2_mat
Uniprot code: O89100
Genome source: Mus musculus
Wild-type ligand: GQPPLVPPRKEKMRGK
Foldx wt ligand score: 5.5
Foldx random average score for Mus musculus: 17.105

Available information for O89100 in MINT (Nov 2008):
Nš of interacting proteins: 14
 Proteins belonging to other specie: 8
Nš of interactions described: 28
 Interactions with other species: 14

Genome scanning information:
Subcellular location: False
Proteins in genome Mus musculus: 58346
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 13900
Total scanned proteins: 44446
 Total fragments: 20108935
Proteins after random average filtering: 44433
 Total fragments: 9893739
Proteins after disorder filtering: 25591
 Total fragments: 387102
Proteins after pattern filtering: 17597
 Total fragments: 144116
Proteins after MINT filtering: 6
 Total fragments: 133


Prediction of know targets:

Ligand peptide Sequence Foldx score ΔGbinding ΔΔG
Reference wt

GQPPLVPPRKEKMRGK

5.50

-21.33

0.00

Best peptides

RRRPHRFTRKKRRKHQ

0.00

-18.42

2.91

         
Interactors      
Q9QUN3

PAAPSPLPRAGKKPAT

8.02

-16.41

4.92

TVQSPVFPPTQKPVHQ

11.03

-12.28

9.05

VFPPTQKPVHQKPVPL

12.09

-13.61

7.72

P70218

NIPPPLPPKPKFRSPS

12.47

-15.17

6.16

IPPPLPPKPKFRSPSD

12.92

-14.58

6.75

RCASGPPPRTPRPGPP

13.36

-18.40

2.93

Q80U87

SSAPPSTPPTHKVKPQ

11.92

-14.34

6.99

PTNTVHMYPPEMAPSS

14.86

-11.56

9.77

VHMYPPEMAPSSAPPS

16.09

-8.60

12.73

Q9Z1S8

DFQPGSPSPHRKPSTS

11.74

-12.78

8.55

DSAIAPPPRPPKPSQA

12.93

-16.41

4.92

PHHFDPLGYPSTALPI

15.08

-12.20

9.13

O35601

KPRFPRHTFGQKPSLS

7.76

-15.72

5.61

PPVPSLPPRNIKPPLD

11.32

-15.96

5.37

PFKPPKEDPEDKDHGA

11.41

-12.67

8.66

Q9QYY0

PRPPKPHPTHDRSPVE

11.50

-15.45

5.88

GFRSSPKTPPRRPVPV

12.49

-12.70

8.63

TIPDIPPPRPPKPHPT

12.56

-17.50

3.83

 


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