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Matrix information:
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ADAN-name: 1TZE2.PDB
Scoring matrix: 1TZE2_mat
Uniprot code: P62993
Genome source: Homo sapiens
Wild-type ligand: KPFyVNV
Foldx wt ligand score: 4.41
Foldx random average score for Homo sapiens: 18.780 Available information for P62993 in MINT (Nov 2008):
Nš of interacting proteins: 64
Proteins belonging to other specie: 6
Nš of interactions described: 157
Interactions with other species: 28
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22248677
Proteins after random average filtering: 48052
Total fragments: 11831947
Proteins after disorder filtering: 36863
Total fragments: 964378
Proteins after pattern filtering: 18809
Total fragments: 110712
Proteins after MINT filtering: 35
Total fragments: 334
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
KPFyVNV |
4.41
|
-16.03 |
0.00 |
| Best peptides |
syDyyNM |
0.00
|
-17.63 |
-1.60 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P05067 |
CAPFFYG |
16.42
|
1.44 |
17.47 |
|
PFFYGGC |
16.95
|
-3.55 |
12.48 |
|
APFFYGG |
17.26
|
-4.41 |
11.62 |
| O43609 |
GDSYSDN |
14.51
|
-5.92 |
10.11 |
| Q07890 |
LPPKTYK |
17.81
|
5.00 |
21.03 |
| P35968 |
GYHSDDT |
17.04
|
-3.02 |
13.01 |
|
QSGYHSD |
17.37
|
-3.68 |
12.35 |
|
YHSDDTD |
18.04
|
-4.05 |
11.98 |
| Q6S383 |
YYSPYSV |
17.36
|
-3.50 |
12.53 |
|
GRRYASG |
17.74
|
-2.67 |
13.36 |
|
YSPYSVS |
18.00
|
-3.98 |
12.05 |
| O43561 |
EDDYHNP |
12.63
|
-9.37 |
6.66 |
|
NPGYLVV |
15.13
|
-5.23 |
10.80 |
|
AYPPVTS |
16.25
|
-4.73 |
11.30 |
| P21860 |
DYEYMNR |
10.50
|
-7.27 |
8.76 |
|
GYMPMNQ |
10.80
|
-9.77 |
6.26 |
|
YPDVQNE |
13.66
|
-8.70 |
7.33 |
| Q07912 |
PPAYDDV |
14.68
|
-4.40 |
11.63 |
|
QTNYAFV |
15.43
|
0.64 |
16.67 |
|
PPPAYDD |
15.61
|
-4.94 |
11.09 |
| Q15303 |
NPDYWNH |
10.36
|
-9.94 |
6.09 |
|
NPEYHNA |
10.40
|
-8.94 |
7.09 |
|
YHNASNG |
13.45
|
-5.52 |
10.51 |
| P00533 |
NPVYHNQ |
11.25
|
-7.94 |
8.09 |
|
TTYQMDV |
14.31
|
-4.61 |
11.42 |
|
PDYQQDF |
14.71
|
-5.65 |
10.38 |
| P62993 |
YVTPVNR |
11.97
|
-8.13 |
7.90 |
|
MFPRNYV |
17.80
|
3.83 |
19.86 |
|
PRNYVTP |
18.27
|
-4.67 |
11.36 |
| P22681 |
EDDGYDV |
14.28
|
-5.39 |
10.64 |
|
EEDTEYM |
14.65
|
3.22 |
19.25 |
|
SPNYDDD |
15.37
|
-4.61 |
11.42 |
| P29353 |
DHQYYND |
12.89
|
-9.46 |
6.57 |
|
HQYYNDF |
16.19
|
-4.97 |
11.06 |
|
YNDFPGK |
17.29
|
-3.71 |
12.32 |
| Q13191 |
SQDYDQL |
15.08
|
-6.15 |
9.88 |
|
GSEEYDV |
15.12
|
-3.48 |
12.55 |
|
PSDYDLL |
15.79
|
-9.32 |
6.71 |
| Q13480 |
PYQLINV |
10.75
|
-6.79 |
9.24 |
|
ELYVFNT |
13.57
|
-8.34 |
7.69 |
|
DSSLYNL |
13.81
|
-9.69 |
6.34 |
| P08729 |
SSSLYGL |
17.86
|
-2.70 |
13.33 |
|
GSSSLYG |
18.75
|
4.02 |
20.05 |
| Q13905 |
PSQYDNI |
12.42
|
-8.80 |
7.23 |
|
HPSQYDN |
15.98
|
-3.39 |
12.64 |
|
SYERHPS |
17.46
|
-3.38 |
12.65 |
| P07949 |
GYGTCNC |
12.59
|
-5.49 |
10.54 |
|
FPRYPND |
15.06
|
-8.43 |
7.60 |
|
KAGYGTC |
16.63
|
-5.59 |
10.44 |
| Q07889 |
YKREHTH |
15.81
|
-4.19 |
11.84 |
|
KKYSYPL |
17.14
|
-2.22 |
13.81 |
|
LPPKTYK |
17.81
|
5.00 |
21.03 |
| Q07666 |
GDSEYYD |
16.24
|
4.40 |
20.43 |
|
DSEYYDY |
16.35
|
-4.89 |
11.14 |
|
SEYYDYG |
17.03
|
-0.75 |
15.28 |
| Q9UKW4 |
IRNYSGT |
17.49
|
-3.49 |
12.54 |
|
QVIRNYS |
18.56
|
3.44 |
19.47 |
| Q9UQC2 |
EDNYVPM |
14.49
|
-6.67 |
9.36 |
|
VHGFYSL |
14.71
|
-2.15 |
13.88 |
|
EENYVPM |
14.77
|
-7.46 |
8.57 |
| P11137 |
QGTYSNT |
14.30
|
-8.50 |
7.53 |
|
GDDYLPA |
14.69
|
-6.49 |
9.54 |
|
GTYSNTK |
16.17
|
-3.65 |
12.38 |
| P48634 |
PPPYLAS |
15.41
|
-4.46 |
11.57 |
|
LYPEVFY |
15.46
|
1.96 |
17.99 |
|
GYPKYQK |
15.78
|
-1.43 |
14.60 |
| Q04695 |
GYGSSFG |
17.60
|
3.10 |
19.13 |
|
CYSFGSG |
17.61
|
-2.07 |
13.96 |
|
SCYSFGS |
18.00
|
-1.08 |
14.95 |
| P27986 |
GYNETTG |
16.81
|
-3.44 |
12.59 |
|
YNETTGE |
17.68
|
-1.72 |
14.31 |
| O43597 |
CTYPRPL |
17.49
|
-3.26 |
12.77 |
|
KECTYPR |
17.78
|
-3.11 |
12.92 |
| Q13444 |
CYCEEGW |
16.84
|
-2.77 |
13.26 |
|
SGSYVSC |
18.42
|
-3.82 |
12.21 |
|
PSGSYVS |
18.54
|
-4.56 |
11.47 |
| P05787 |
AYGGLTS |
16.66
|
-4.08 |
11.95 |
|
GLSYSLG |
17.43
|
-5.45 |
10.58 |
|
GLSSAYG |
18.09
|
3.79 |
19.82 |
| Q8WV28 |
DSDYENP |
16.81
|
-9.29 |
6.74 |
|
DFDSDYE |
17.70
|
1.98 |
18.01 |
|
SDYENPD |
17.73
|
-3.29 |
12.74 |
| P05783 |
SVYAGAG |
18.11
|
-1.47 |
14.56 |
| P13987 |
SLQCYNC |
13.46
|
-7.85 |
8.18 |
|
YNCPNPT |
18.47
|
-2.02 |
14.01 |
| P04626 |
QPEYVNQ |
10.34
|
-9.39 |
6.64 |
|
NLYYWDQ |
13.67
|
-6.98 |
9.05 |
|
YVAPLTC |
15.07
|
-4.68 |
11.35 |
| Q13094 |
NSMYIDR |
14.36
|
-7.35 |
8.68 |
|
DYESPNE |
15.45
|
-2.94 |
13.09 |
|
EDDADYE |
15.70
|
0.60 |
16.63 |
| P58107 |
YRDPATG |
16.28
|
-2.55 |
13.48 |
|
YPDPYGG |
18.10
|
-1.15 |
14.88 |
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