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Matrix information:
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ADAN-name: 1QG12.PDB
Scoring matrix: 1QG12_mat
Uniprot code: P62993
Genome source: Homo sapiens
Wild-type ligand: DDPSyVNVQNLDK
Foldx wt ligand score: 24.03
Foldx random average score for Homo sapiens: 25.072 Available information for P62993 in MINT (Nov 2008):
Nš of interacting proteins: 64
Proteins belonging to other specie: 6
Nš of interactions described: 157
Interactions with other species: 28
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 21960385
Proteins after random average filtering: 48022
Total fragments: 11584894
Proteins after disorder filtering: 34718
Total fragments: 1211677
Proteins after pattern filtering: 18830
Total fragments: 201121
Proteins after MINT filtering: 32
Total fragments: 580
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
DDPSyVNVQNLDK |
24.03
|
2.21 |
0.00 |
| Best peptides |
DDGGGyGGyssps |
0.00
|
10.74 |
8.53 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P05067 |
FFYGGCGGNRNNF |
5.73
|
0.41 |
-1.80 |
|
PFFYGGCGGNRNN |
10.70
|
0.95 |
-1.26 |
|
DVWWGGADTDYAD |
12.96
|
-0.29 |
-2.50 |
| O43609 |
CSNDDEGDSYSDN |
12.15
|
0.68 |
-1.53 |
|
NDDEGDSYSDNPC |
14.11
|
1.06 |
-1.15 |
|
SNDDEGDSYSDNP |
14.87
|
2.34 |
0.13 |
| P35968 |
VASEGSNQTSGYQ |
15.39
|
2.60 |
0.39 |
|
TSGYQSGYHSDDT |
15.74
|
3.70 |
1.49 |
|
NQTSGYQSGYHSD |
17.00
|
2.96 |
0.75 |
| Q6S383 |
YSVSGSGSTAGSR |
11.17
|
2.14 |
-0.07 |
|
GRRYASGSSASLG |
13.24
|
2.08 |
-0.13 |
|
AYSDPSTGEPATY |
14.87
|
2.71 |
0.50 |
| O43561 |
DADEDEDDYHNPG |
14.16
|
-0.48 |
-2.69 |
|
CEDADEDEDDYHN |
14.54
|
0.18 |
-2.03 |
|
EDADEDEDDYHNP |
17.46
|
-1.35 |
-3.56 |
| Q13191 |
FYLYPDGRSYNPD |
16.38
|
3.16 |
0.95 |
|
LYPDGRSYNPDLT |
16.63
|
0.88 |
-1.33 |
|
YDQLPSCSDGSQA |
17.39
|
0.47 |
-1.74 |
| Q07912 |
QHLGGVKKPTYDP |
14.39
|
2.73 |
0.52 |
|
PAGPSQGQTNYAF |
14.73
|
2.95 |
0.74 |
|
VPAGPSQGQTNYA |
14.87
|
2.80 |
0.59 |
| Q15303 |
GELDEEGYMTPMR |
13.22
|
0.63 |
-1.58 |
|
RSPRGELDEEGYM |
13.72
|
1.03 |
-1.18 |
|
EYHNASNGPPKAE |
15.36
|
1.89 |
-0.32 |
| P00533 |
NCTYGCTGPGLEG |
12.49
|
2.99 |
0.78 |
|
KRPAGSVQNPVYH |
15.07
|
3.25 |
1.04 |
|
LNPAPSRDPHYQD |
16.52
|
1.36 |
-0.85 |
| P62993 |
CHGQTGMFPRNYV |
20.99
|
5.34 |
3.13 |
|
TGMFPRNYVTPVN |
21.07
|
1.31 |
-0.90 |
| P22681 |
EQCEGEEDTEYMT |
14.24
|
1.48 |
-0.73 |
|
NEDDGYDVPKPPV |
15.13
|
0.67 |
-1.54 |
|
DRPYSVGAESRPQ |
15.25
|
2.24 |
0.03 |
| P29353 |
YNDFPGKEPPLGG |
15.18
|
1.90 |
-0.31 |
|
QYYNDFPGKEPPL |
20.56
|
1.27 |
-0.94 |
|
EEPPDHQYYNDFP |
21.48
|
-0.17 |
-2.38 |
| Q13094 |
QDGEDDGDYESPN |
11.22
|
-2.35 |
-4.56 |
|
DDQDGEDDGDYES |
12.11
|
-0.92 |
-3.13 |
|
DQDGEDDGDYESP |
12.29
|
0.25 |
-1.96 |
| Q13480 |
SYCIPTAGMSPSR |
16.00
|
2.54 |
0.33 |
|
SHDSEENYVPMNP |
16.73
|
1.70 |
-0.51 |
|
RAPSASVDSSLYN |
17.29
|
1.80 |
-0.41 |
| P08729 |
ARPGGLGSSSLYG |
11.11
|
-0.22 |
-2.43 |
|
RPGGLGSSSLYGL |
23.61
|
2.70 |
0.49 |
| Q13905 |
SHSYGGESPRLSP |
15.56
|
3.20 |
0.99 |
|
GGSHSYGGESPRL |
17.23
|
4.83 |
2.62 |
|
GSHSYGGESPRLS |
17.40
|
2.81 |
0.60 |
| P07949 |
PGYLGSGGSRNSS |
7.78
|
0.67 |
-1.54 |
|
KVGPGYLGSGGSR |
12.68
|
-0.73 |
-2.94 |
|
YLGSGGSRNSSSL |
12.81
|
3.33 |
1.12 |
| Q07889 |
LPRFPKKYSYPLK |
16.95
|
1.36 |
-0.85 |
|
PKLPPKTYKREHT |
19.53
|
1.54 |
-0.67 |
|
KYSYPLKSPGVRP |
20.79
|
0.02 |
-2.19 |
| Q07666 |
YYSQSQGDSEYYD |
14.91
|
1.36 |
-0.85 |
|
SQSQGDSEYYDYG |
16.74
|
2.22 |
0.01 |
|
YGQDDWNGTRPSL |
17.55
|
-3.56 |
-5.77 |
| Q9UKW4 |
VIRNYSGTPPPAL |
19.54
|
3.09 |
0.88 |
|
QVIRNYSGTPPPA |
20.24
|
1.95 |
-0.26 |
| Q9UQC2 |
STDSGDSEENYVP |
14.82
|
3.05 |
0.84 |
|
AHHFDSLGYPSTT |
15.15
|
0.99 |
-1.22 |
|
TDSGDSEENYVPM |
15.56
|
-0.32 |
-2.53 |
| P11137 |
ENLSGESGTFYEG |
12.00
|
0.82 |
-1.39 |
|
SGSMDEGDDYLPA |
12.72
|
0.48 |
-1.73 |
|
GEHGSQGTYSNTK |
14.55
|
2.53 |
0.32 |
| P48634 |
CRGRGRGEYFARG |
11.14
|
0.79 |
-1.42 |
|
EVFYGSAGPSSSQ |
11.58
|
-0.24 |
-2.45 |
|
ARGRGFRGTYGGR |
12.33
|
0.25 |
-1.96 |
| Q04695 |
CYSFGSGGGYGSS |
7.44
|
1.03 |
-1.18 |
|
GSGGGYGSSFGGV |
7.78
|
-0.01 |
-2.22 |
|
SFGSGGGYGSSFG |
8.10
|
1.58 |
-0.63 |
| P27986 |
NGYNETTGERGDF |
15.94
|
2.07 |
-0.14 |
|
GYNETTGERGDFP |
23.83
|
2.48 |
0.27 |
| Q13444 |
CGRNPSGSYVSCT |
12.28
|
1.19 |
-1.02 |
|
HCYCEEGWAPPDC |
15.55
|
2.42 |
0.21 |
|
SCGRNPSGSYVSC |
19.76
|
3.59 |
1.38 |
| P05787 |
GLGGGYGGASGMG |
4.50
|
-1.02 |
-3.23 |
|
NFRGGLGGGYGGA |
7.70
|
-1.00 |
-3.21 |
|
RGGLGGGYGGASG |
8.81
|
2.06 |
-0.15 |
| Q8WV28 |
SDDFDSDYENPDE |
15.54
|
0.92 |
-1.29 |
|
DFDSDYENPDEHS |
17.45
|
-1.38 |
-3.59 |
|
NYIHPTESSSPPP |
21.89
|
6.87 |
4.66 |
| P05783 |
SVYAGAGGSGSRI |
7.16
|
0.68 |
-1.53 |
|
YAGAGGSGSRISV |
9.23
|
2.05 |
-0.16 |
|
VYAGAGGSGSRIS |
11.46
|
2.18 |
-0.03 |
| P13987 |
CYNCPNPTADCKT |
23.11
|
4.95 |
2.74 |
|
LQCYNCPNPTADC |
23.69
|
3.58 |
1.37 |
| P04626 |
EYLTPQGGAAPQP |
12.93
|
0.57 |
-1.64 |
|
PLPSETDGYVAPL |
13.16
|
-0.46 |
-2.67 |
|
SETDGYVAPLTCS |
16.19
|
0.86 |
-1.35 |
| P21860 |
RDGGGPGGDYAAM |
6.32
|
0.23 |
-1.98 |
|
DGGGPGGDYAAMG |
7.85
|
0.11 |
-2.10 |
|
QRDGGGPGGDYAA |
11.72
|
1.99 |
-0.22 |
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