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Matrix information:
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ADAN-name: 1PIC2.PDB
Scoring matrix: 1PIC2_mat
Uniprot code: P27986
Genome source: Homo sapiens
Wild-type ligand: yVPML
Foldx wt ligand score: 3.05
Foldx random average score for Homo sapiens: 8.195 Available information for P27986 in MINT (Nov 2008):
Nš of interacting proteins: 27
Proteins belonging to other specie: 5
Nš of interactions described: 83
Interactions with other species: 11
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22344792
Proteins after random average filtering: 48058
Total fragments: 14907743
Proteins after disorder filtering: 38280
Total fragments: 2317369
Proteins after pattern filtering: 19209
Total fragments: 101711
Proteins after MINT filtering: 15
Total fragments: 150
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
yVPML |
3.05
|
0.16 |
0.00 |
| Best peptides |
yWsMP |
0.00
|
13.09 |
12.93 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P00533 |
TYQMD |
2.21
|
2.43 |
2.27 |
|
DYQQD |
4.58
|
6.07 |
5.91 |
|
GKYSF |
4.65
|
6.14 |
5.98 |
| P62993 |
NYVTP |
4.41
|
5.08 |
4.92 |
|
YVTPV |
7.47
|
4.60 |
4.44 |
| P22681 |
EYMTP |
2.97
|
2.53 |
2.37 |
|
GYDVP |
3.00
|
4.50 |
4.34 |
|
PYSVG |
4.11
|
4.44 |
4.28 |
| Q07666 |
EYYDY |
6.45
|
6.33 |
6.17 |
|
YSQSQ |
7.91
|
6.62 |
6.46 |
| P35568 |
GDYMP |
2.11
|
1.23 |
1.07 |
|
CYYGP |
2.33
|
2.66 |
2.50 |
|
PAYPP |
2.37
|
1.99 |
1.83 |
| P42336 |
VYPPN |
3.04
|
2.25 |
2.09 |
|
YVYPP |
4.57
|
1.42 |
1.26 |
|
AMYVY |
5.74
|
4.37 |
4.21 |
| Q9UQC2 |
SVYIP |
3.78
|
2.45 |
2.29 |
|
DNYVP |
3.93
|
2.58 |
2.42 |
|
YVPMN |
4.67
|
2.26 |
2.10 |
| P29353 |
QYYND |
5.36
|
6.05 |
5.89 |
| Q9Y5K6 |
TCYSP |
4.52
|
4.50 |
4.34 |
|
CYSPK |
4.79
|
4.93 |
4.77 |
|
TVYPK |
5.08
|
9.03 |
8.87 |
| P43405 |
YDVVN |
7.84
|
6.43 |
6.27 |
|
YSFPK |
7.87
|
6.46 |
6.30 |
| O15455 |
HYLCN |
4.15
|
5.03 |
4.87 |
|
HYHGF |
5.37
|
7.22 |
7.06 |
|
SHYLC |
6.63
|
7.59 |
7.43 |
| P04626 |
GYVAP |
3.06
|
2.86 |
2.70 |
|
EYLTP |
3.28
|
3.58 |
3.42 |
|
PEYVN |
3.98
|
4.32 |
4.16 |
| P21860 |
GYVMP |
2.23
|
0.97 |
0.81 |
|
GYMPM |
3.63
|
4.22 |
4.06 |
|
SGYMP |
3.65
|
2.66 |
2.50 |
| P06239 |
TYEGS |
4.18
|
5.46 |
5.30 |
|
YEGSN |
6.74
|
5.26 |
5.10 |
|
VTYEG |
8.06
|
7.32 |
7.16 |
| Q13480 |
SYDIP |
3.08
|
1.55 |
1.39 |
|
CYDIP |
3.30
|
3.87 |
3.71 |
|
LYNLP |
3.33
|
1.43 |
1.27 |
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