ADAN database

 

Scanning Information and Binding Energy of Known Targets

Matrix information:                                                    (Help)
ADAN-name: 1MW42.PDB
Scoring matrix: 1MW42_mat
Uniprot code: Q14451
Genome source: Homo sapiens
Wild-type ligand: PQPEyVNQPD
Foldx wt ligand score: 47.62
Foldx random average score for Homo sapiens: 39.847

Available information for Q14451 in MINT (Nov 2008):
Nš of interacting proteins: 3
 Proteins belonging to other specie: 0
Nš of interactions described: 7
 Interactions with other species: 0

Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
 Total fragments: 22104514
Proteins after random average filtering: 48041
 Total fragments: 10373867
Proteins after disorder filtering: 35890
 Total fragments: 1590551
Proteins after pattern filtering: 19473
 Total fragments: 180558
Proteins after MINT filtering: 2
 Total fragments: 39


Prediction of know targets:

Ligand peptide Sequence Foldx score ΔGbinding ΔΔG
Reference wt

PQPEyVNQPD

47.62

15.55

0.00

Best peptides

sDGGGGGNyG

0.00

17.13

1.58

         
Interactors      
P04626

SMPNPEGRYT

20.94

8.05

-7.50

EYLTPQGGAA

21.79

7.89

-7.66

SETDGYVAPL

25.76

8.27

-7.28

P21860

DGGGPGGDYA

10.29

6.28

-9.27

GGGPGGDYAA

14.71

5.84

-9.71

SLLSPSSGYM

22.64

8.49

-7.06

 


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