ADAN database

 

Scanning Information and Binding Energy of Known Targets

Matrix information:                                                    (Help)
ADAN-name: 1LCJ2.PDB
Scoring matrix: 1LCJ2_mat
Uniprot code: P06239
Genome source: Homo sapiens
Wild-type ligand: EPQyEEIPIYL
Foldx wt ligand score: 6.16
Foldx random average score for Homo sapiens: 17.472

Available information for P06239 in MINT (Nov 2008):
Nš of interacting proteins: 20
 Proteins belonging to other specie: 3
Nš of interactions described: 50
 Interactions with other species: 22

Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
 Total fragments: 22056464
Proteins after random average filtering: 48028
 Total fragments: 11159156
Proteins after disorder filtering: 33716
 Total fragments: 727985
Proteins after pattern filtering: 17125
 Total fragments: 109186
Proteins after MINT filtering: 9
 Total fragments: 79


Prediction of know targets:

Ligand peptide Sequence Foldx score ΔGbinding ΔΔG
Reference wt

EPQyEEIPIYL

6.16

-16.65

0.00

Best peptides

yssyDyMPyDy

0.00

-18.04

-1.39

         
Interactors      
P04150

GYSSPSMRPDV

16.59

-3.70

12.95

SNGYSSPSMRP

17.29

-4.69

11.96

P27986

GYNETTGERGD

17.18

-3.17

13.48

P22681

EEDTEYMTPSS

12.98

-8.67

7.98

DDGYDVPKPPV

13.82

-9.84

6.81

SENEDDGYDVP

13.98

-6.18

10.47

Q07666

YGQDDWNGTRP

15.45

-4.68

11.97

QSQGDSEYYDY

17.34

-3.46

13.19

Q13444

GVCDSNRHCYC

14.99

-4.12

12.53

YCEEGWAPPDC

16.06

-3.58

13.07

RHCYCEEGWAP

16.14

-4.05

12.60

Q13094

EDDYESPNDDQ

12.32

-10.91

5.74

DADYEPPPSND

12.88

-9.68

6.97

FEEDDYESPND

13.30

-8.08

8.57

Q12959

NDGYAPPDITN

15.37

-9.49

7.16

YMNDGYAPPDI

15.48

-4.21

12.44

TDSLETPTYVN

15.67

-6.17

10.48

P43405

SYSFPKPGHRK

16.13

-4.72

11.93

P43403

PMPMDTSVYES

14.91

-5.95

10.70

MPMDTSVYESP

15.40

-4.16

12.49

YTPEPARITSP

16.10

-2.24

14.41

 


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