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Matrix information:
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ADAN-name: 1KSW2.PDB
Scoring matrix: 1KSW2_mat
Uniprot code: P12931
Genome source: Homo sapiens
Wild-type ligand: EPQyQPGENL
Foldx wt ligand score: 6.39
Foldx random average score for Homo sapiens: 15.671 Available information for P12931 in MINT (Nov 2008):
Nš of interacting proteins: 50
Proteins belonging to other specie: 11
Nš of interactions described: 106
Interactions with other species: 20
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22104514
Proteins after random average filtering: 48045
Total fragments: 11567075
Proteins after disorder filtering: 35387
Total fragments: 924192
Proteins after pattern filtering: 18023
Total fragments: 125391
Proteins after MINT filtering: 24
Total fragments: 266
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
EPQyQPGENL |
6.39
|
-9.48 |
0.00 |
| Best peptides |
EEsyLDGNMs |
0.00
|
-6.26 |
3.22 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P49023 |
SSSPVYGSSA |
13.02
|
1.58 |
11.06 |
|
LPGALSPLYG |
13.52
|
-3.92 |
5.56 |
|
PYSYPTGNHT |
14.35
|
0.09 |
9.57 |
| Q8WUM4 |
GQAPYPGPQQ |
12.57
|
-1.63 |
7.85 |
|
PSIPTPAYQS |
13.17
|
-2.44 |
7.04 |
|
MGYNPYAYGQ |
14.32
|
-1.56 |
7.92 |
| P21860 |
EEEDVNGYVM |
9.26
|
-5.13 |
4.35 |
|
PGGDYAAMGA |
10.51
|
-5.67 |
3.81 |
|
DGGGPGGDYA |
11.71
|
0.71 |
10.19 |
| P15941 |
YEKVSAGNGG |
11.90
|
0.01 |
9.49 |
|
PSSTDRSPYE |
12.26
|
-0.85 |
8.63 |
|
SPYEKVSAGN |
13.42
|
-0.42 |
9.06 |
| P09848 |
YGTAAPGVSN |
11.68
|
-2.93 |
6.55 |
|
DGFEGPSGYS |
12.16
|
-3.21 |
6.27 |
|
EGPSGYSQRF |
13.59
|
0.61 |
10.09 |
| P05106 |
CDSDWTGYYC |
11.48
|
-4.94 |
4.54 |
|
DWTGYYCNCT |
12.60
|
-0.80 |
8.68 |
|
CVCIQPGSYG |
13.00
|
0.12 |
9.60 |
| P00533 |
YGCTGPGLEG |
11.91
|
-1.04 |
8.44 |
|
MDVNPEGKYS |
12.61
|
-3.01 |
6.47 |
|
ISLDNPDYQQ |
13.45
|
-2.41 |
7.07 |
| P22681 |
SENEDDGYDV |
9.95
|
-1.78 |
7.70 |
|
EDTEYMTPSS |
10.30
|
-3.28 |
6.20 |
|
EGEEDTEYMT |
10.63
|
-5.33 |
4.15 |
| Q05655 |
DMQDNSGTYG |
12.09
|
-3.85 |
5.63 |
|
NSGTYGKIWE |
12.82
|
-1.27 |
8.21 |
|
DNSGTYGKIW |
13.88
|
1.45 |
10.93 |
| P03372 |
QTGLPYGPGS |
12.66
|
-0.96 |
8.52 |
|
FYRPNSDNRR |
13.55
|
0.52 |
10.00 |
|
TGLPYGPGSE |
14.11
|
-1.14 |
8.34 |
| Q8TBB1 |
EPGLDNPAYV |
12.30
|
-3.12 |
6.36 |
|
PGLDNPAYVS |
13.13
|
-3.48 |
6.00 |
|
LDNPAYVSSA |
13.71
|
-2.80 |
6.68 |
| P25092 |
YPVDMSPTFT |
15.55
|
-2.18 |
7.30 |
| Q05397 |
QVSGYPGSHG |
13.74
|
0.22 |
9.70 |
|
PGYPSPRSSE |
14.61
|
1.11 |
10.59 |
|
VSGYPGSHGI |
14.76
|
0.41 |
9.89 |
| Q07666 |
QGDSEYYDYG |
13.29
|
-2.92 |
6.56 |
|
YYSQSQGDSE |
13.94
|
1.43 |
10.91 |
|
YSQSQGDSEY |
14.70
|
0.85 |
10.33 |
| Q9C0H9 |
GGGPLYGDGY |
9.75
|
0.17 |
9.65 |
|
LYGDGYGFRL |
11.99
|
-2.76 |
6.72 |
|
DPFAYPGAGG |
12.47
|
-0.09 |
9.39 |
| P55196 |
YAGDFDGMSM |
10.49
|
-3.97 |
5.51 |
|
ERADGSGYGS |
10.97
|
-0.57 |
8.91 |
|
EGFELYNNST |
11.63
|
-2.06 |
7.42 |
| O15455 |
YHGFPVRLFD |
15.27
|
1.35 |
10.83 |
|
LSSHYLCNTP |
15.41
|
-0.92 |
8.56 |
| Q9H5V8 |
AVGIYNGNIN |
10.82
|
-0.07 |
9.41 |
|
NKGPAVGIYN |
11.48
|
-1.76 |
7.72 |
|
ESESEPYTFS |
11.92
|
-2.60 |
6.88 |
| Q13444 |
CDSNRHCYCE |
14.73
|
-1.35 |
8.13 |
|
VCDSNRHCYC |
15.29
|
-0.31 |
9.17 |
|
GRNPSGSYVS |
15.32
|
0.02 |
9.50 |
| Q9Y5K6 |
CYSPKPSVYL |
13.25
|
1.37 |
10.85 |
|
DTCYSPKPSV |
15.38
|
-2.77 |
6.71 |
| P56945 |
GGVVDSGVYA |
11.74
|
-0.35 |
9.13 |
|
PGGPAQDIYQ |
11.76
|
-2.25 |
7.23 |
|
LYDVPPGLRR |
12.70
|
-0.75 |
8.73 |
| P07550 |
YGNGYSSNGN |
11.79
|
1.06 |
10.54 |
|
NGYSSNGNTG |
13.07
|
1.21 |
10.69 |
|
AYGNGYSSNG |
15.67
|
1.08 |
10.56 |
| P06241 |
QHYPSFGVTS |
13.39
|
1.60 |
11.08 |
|
FGVTSIPNYN |
13.94
|
0.37 |
9.85 |
|
SSGYRYGTDP |
14.59
|
-1.80 |
7.68 |
| Q16832 |
EQGSNSTYDR |
13.45
|
-2.51 |
6.97 |
|
SEQGSNSTYD |
13.61
|
3.03 |
12.51 |
|
YPLGMSGGQI |
13.86
|
0.38 |
9.86 |
|
