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Matrix information:
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ADAN-name: 1JYR2.PDB
Scoring matrix: 1JYR2_mat
Uniprot code: P62993
Genome source: Homo sapiens
Wild-type ligand: APSyVNVQN
Foldx wt ligand score: 7.02
Foldx random average score for Homo sapiens: 20.045 Available information for P62993 in MINT (Nov 2008):
Nš of interacting proteins: 64
Proteins belonging to other specie: 6
Nš of interactions described: 157
Interactions with other species: 28
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22152566
Proteins after random average filtering: 48038
Total fragments: 11015883
Proteins after disorder filtering: 35103
Total fragments: 714760
Proteins after pattern filtering: 17597
Total fragments: 100120
Proteins after MINT filtering: 33
Total fragments: 345
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
APSyVNVQN |
7.02
|
-18.80 |
0.00 |
| Best peptides |
HDDyyNKyp |
0.00
|
-20.67 |
-1.87 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P05067 |
WGGADTDYA |
16.84
|
-2.86 |
15.94 |
|
GGADTDYAD |
18.33
|
-2.74 |
16.06 |
|
CAPFFYGGC |
18.44
|
1.28 |
20.08 |
| O43609 |
DDEGDSYSD |
16.98
|
-1.35 |
17.45 |
|
GDSYSDNPC |
17.04
|
-5.72 |
13.08 |
|
NDDEGDSYS |
17.59
|
-8.62 |
10.18 |
| Q07890 |
KLPPKTYKR |
18.33
|
-5.65 |
13.15 |
|
LPPKTYKRE |
18.87
|
3.52 |
22.32 |
| P35968 |
TSGYQSGYH |
19.50
|
-5.29 |
13.51 |
|
QSGYHSDDT |
19.63
|
-3.63 |
15.17 |
|
SGYHSDDTD |
19.98
|
-3.51 |
15.29 |
| Q6S383 |
YSDPSTGEP |
19.37
|
-2.59 |
16.21 |
|
YYSPYSVSG |
19.68
|
-3.43 |
15.37 |
| O43561 |
ADEDEDDYH |
14.64
|
-9.26 |
9.54 |
|
DEDEDDYHN |
15.00
|
-8.78 |
10.02 |
|
EDDYHNPGY |
15.63
|
-11.38 |
7.42 |
| Q13191 |
PSDYDLLIP |
13.76
|
-6.85 |
11.95 |
|
SDYDLLIPP |
14.13
|
-10.08 |
8.72 |
|
EDDDEYKIP |
15.05
|
-2.03 |
16.77 |
| Q07912 |
IDELYLGNP |
13.92
|
-7.36 |
11.44 |
|
SQGQTNYAF |
15.87
|
-3.47 |
15.33 |
|
DRIDELYLG |
16.58
|
-6.85 |
11.95 |
| Q15303 |
NPDYWNHSL |
12.96
|
-11.90 |
6.90 |
|
NPEYHNASN |
13.85
|
-9.61 |
9.19 |
|
YHNASNGPP |
16.58
|
-5.65 |
13.15 |
| P00533 |
CPPLMLYNP |
14.16
|
-9.85 |
8.95 |
|
NPVYHNQPL |
14.71
|
-11.08 |
7.72 |
|
YQMDVNPEG |
16.36
|
-8.23 |
10.57 |
| P62993 |
GMFPRNYVT |
15.53
|
-8.12 |
10.68 |
|
MFPRNYVTP |
19.63
|
4.29 |
23.09 |
| P22681 |
EDDGYDVPK |
15.46
|
-4.43 |
14.37 |
|
NYDDDDDER |
15.55
|
-7.80 |
11.00 |
|
SPNYDDDDD |
15.63
|
-5.60 |
13.20 |
| P29353 |
DHQYYNDFP |
14.90
|
-8.85 |
9.95 |
|
HQYYNDFPG |
15.90
|
-4.80 |
14.00 |
|
YYNDFPGKE |
18.74
|
-6.27 |
12.53 |
| Q13094 |
VEDDADYEP |
15.14
|
-8.16 |
10.64 |
|
FEEDDYESP |
16.09
|
-0.44 |
18.36 |
|
GEDDGDYES |
16.25
|
-6.14 |
12.66 |
| Q13480 |
HDSEENYVP |
13.09
|
-10.69 |
8.11 |
|
ELYVFNTPS |
14.88
|
-8.94 |
9.86 |
|
PPPYQLINV |
15.43
|
-9.99 |
8.81 |
| P08729 |
LGSSSLYGL |
18.99
|
-4.78 |
14.02 |
|
GLGSSSLYG |
19.84
|
-1.72 |
17.08 |
| Q13905 |
PSQYDNISG |
13.43
|
-9.38 |
9.42 |
|
HPSQYDNIS |
17.47
|
-4.71 |
14.09 |
|
QYDNISGED |
18.86
|
-5.50 |
13.30 |
| P07949 |
FPRYPNDSV |
17.37
|
-4.06 |
14.74 |
|
VGPGYLGSG |
17.58
|
-3.37 |
15.43 |
|
KAGYGTCNC |
18.08
|
-4.72 |
14.08 |
| Q07889 |
KLPPKTYKR |
18.33
|
-5.65 |
13.15 |
|
KYSYPLKSP |
18.56
|
-4.17 |
14.63 |
|
LPPKTYKRE |
18.87
|
3.52 |
22.32 |
| Q07666 |
YGQDDWNGT |
17.60
|
3.02 |
21.82 |
|
PPAPETYEE |
18.89
|
-4.97 |
13.83 |
|
GDSEYYDYG |
19.28
|
3.14 |
21.94 |
| Q9UQC2 |
GDSEENYVP |
14.19
|
-8.83 |
9.97 |
|
TNSEDNYVP |
15.46
|
-7.40 |
11.40 |
|
YVPMQNPVS |
15.93
|
-10.02 |
8.78 |
| P11137 |
MDEGDDYLP |
15.00
|
-3.57 |
15.23 |
|
DEGDDYLPA |
15.64
|
3.60 |
22.40 |
|
QGTYSNTKE |
15.65
|
-9.77 |
9.03 |
| P58107 |
TGYPDPYGG |
19.48
|
-1.86 |
16.94 |
| Q04695 |
YSSCYSFGS |
20.02
|
-2.36 |
16.44 |
| P48634 |
RPPLDFYPP |
16.50
|
-0.50 |
18.30 |
|
RGEYFARGR |
16.91
|
-5.56 |
13.24 |
|
PPPSFLYSP |
17.40
|
-8.19 |
10.61 |
| P27986 |
NGYNETTGE |
19.32
|
-4.42 |
14.38 |
| O43597 |
KECTYPRPL |
18.67
|
-3.67 |
15.13 |
|
KCKECTYPR |
19.21
|
-3.06 |
15.74 |
| Q13444 |
SGSYVSCTP |
18.46
|
-4.49 |
14.31 |
|
CDSNRHCYC |
19.52
|
7.60 |
26.40 |
|
HCYCEEGWA |
19.80
|
-1.32 |
17.48 |
| P05787 |
GLSYSLGSS |
17.65
|
-6.62 |
12.18 |
|
AGGLSSAYG |
19.06
|
-1.78 |
17.02 |
|
AYGGLTSPG |
19.17
|
-2.79 |
16.01 |
| Q8WV28 |
SDDFDSDYE |
14.23
|
-11.13 |
7.67 |
|
DSDYENPDE |
16.14
|
-9.97 |
8.83 |
|
DDFDSDYEN |
16.38
|
-8.40 |
10.40 |
| P13987 |
SLQCYNCPN |
14.38
|
-6.67 |
12.13 |
| P04626 |
SPAFDNLYY |
11.82
|
-8.27 |
10.53 |
|
QPEYVNQPD |
12.42
|
-7.87 |
10.93 |
|
PAFDNLYYW |
16.67
|
-5.55 |
13.25 |
| P21860 |
EEEDVNGYV |
12.20
|
-8.24 |
10.56 |
|
DYEYMNRQR |
12.28
|
-14.56 |
4.24 |
|
YPDVQNECR |
12.98
|
-13.55 |
5.25 |
|
