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Matrix information:
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ADAN-name: 1IO62.PDB
Scoring matrix: 1IO62_mat
Uniprot code: P62993
Genome source: Homo sapiens
Wild-type ligand: RHYRPLPPLP
Foldx wt ligand score: 8.15
Foldx random average score for Homo sapiens: 14.107 Available information for P62993 in MINT (Nov 2008):
Nš of interacting proteins: 64
Proteins belonging to other specie: 6
Nš of interactions described: 157
Interactions with other species: 28
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22104514
Proteins after random average filtering: 48042
Total fragments: 11617012
Proteins after disorder filtering: 35845
Total fragments: 1341680
Proteins after pattern filtering: 25565
Total fragments: 329342
Proteins after MINT filtering: 35
Total fragments: 1193
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
RHYRPLPPLP |
8.15
|
-0.52 |
0.00 |
| Best peptides |
RGGGFIGRLP |
0.00
|
5.72 |
6.24 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| O43609 |
LLGRSPPTRP |
9.24
|
2.40 |
2.92 |
|
LGRSPPTRPV |
12.40
|
6.50 |
7.02 |
|
PPTRPVPGHR |
12.90
|
4.58 |
5.10 |
| Q13177 |
KDGFPSGTPA |
9.25
|
7.53 |
8.05 |
|
EKDGFPSGTP |
11.44
|
5.91 |
6.43 |
|
GFPSGTPALN |
11.44
|
3.68 |
4.20 |
| Q07890 |
PRQNSSPHLP |
7.97
|
1.38 |
1.90 |
|
SPRRRPGDPV |
8.46
|
5.98 |
6.50 |
|
FSLKSPGIRP |
8.69
|
5.20 |
5.72 |
| P35968 |
PQPLPIHVGE |
12.46
|
5.59 |
6.11 |
| P07949 |
VGGHEPGEPR |
5.52
|
4.56 |
5.08 |
|
SDPNWPGESP |
8.12
|
5.71 |
6.23 |
|
IVGGHEPGEP |
8.46
|
1.18 |
1.70 |
| O43561 |
PPLSQPDLLP |
9.97
|
2.59 |
3.11 |
|
RPHTVAPWPP |
10.13
|
4.40 |
4.92 |
|
PIPRSPQPLG |
10.21
|
3.02 |
3.54 |
| Q13094 |
EGRNFPLPLP |
7.73
|
1.34 |
1.86 |
|
LPGKKPPVPK |
8.95
|
4.12 |
4.64 |
|
GRNHSPLPPP |
9.07
|
2.78 |
3.30 |
| Q05193 |
PVPSRPGASP |
7.49
|
4.88 |
5.40 |
|
GSRGPAPGPP |
8.19
|
3.27 |
3.79 |
|
VPPARPGSRG |
8.26
|
5.01 |
5.53 |
| Q13191 |
PCGSPTGSPK |
8.38
|
6.06 |
6.58 |
|
SPVTSPGSSP |
8.77
|
8.00 |
8.52 |
|
PLQIPHLSLP |
9.07
|
2.85 |
3.37 |
| Q07912 |
APGGPAGEGP |
4.84
|
5.91 |
6.43 |
|
PQRGCPGDGP |
4.86
|
4.65 |
5.17 |
|
PGAGGPCILP |
6.97
|
2.28 |
2.80 |
| Q15303 |
PERSPRGELD |
9.16
|
4.68 |
5.20 |
|
RECHPCHPNC |
12.16
|
7.48 |
8.00 |
|
CHPCHPNCTQ |
12.84
|
5.92 |
6.44 |
| P00533 |
VPKRPAGSVQ |
7.85
|
6.72 |
7.24 |
|
SCQKCDPSCP |
10.31
|
3.82 |
4.34 |
|
GCPTNGPKIP |
11.14
|
3.38 |
3.90 |
| P11137 |
RTPGTPGTPS |
5.50
|
4.71 |
5.23 |
|
RTPHTPGTPK |
5.93
|
4.63 |
5.15 |
|
VAPISPGPLT |
8.00
|
6.76 |
7.28 |
| P22681 |
PLPCTPGDCP |
7.28
|
5.62 |
6.14 |
|
LSPHPPGTVD |
8.24
|
5.80 |
6.32 |
|
VPKLPPGEQC |
8.28
|
7.23 |
7.75 |
| P18031 |
SPAKGEPSLP |
9.61
|
3.85 |
4.37 |
|
PAKGEPSLPE |
11.15
|
6.18 |
6.70 |
|
PPEHIPPPPR |
11.56
|
4.81 |
5.33 |
| P29353 |
AVGGAGPPNP |
8.17
|
3.67 |
4.19 |
|
PVGQPVGGDP |
8.51
|
6.90 |
7.42 |
|
PESGPLPLLQ |
8.96
|
2.15 |
2.67 |
| Q9H0H5 |
FVDGPPGPVK |
8.08
|
5.68 |
6.20 |
|
GPPGPVKKTR |
9.00
|
2.99 |
3.51 |
|
RDRCPLPCIP |
9.58
|
-0.24 |
0.28 |
| P63010 |
LDLGPPVNVP |
11.58
|
4.06 |
4.58 |
|
GQSFIPSSVP |
12.68
|
6.33 |
6.85 |
|
FIPSSVPATF |
12.98
|
3.97 |
4.49 |
| P48634 |
LPPGPIGTER |
4.28
|
1.54 |
2.06 |
|
GNWGPPGDYP |
5.34
|
4.41 |
4.93 |
|
PHRGPAGNWG |
5.69
|
6.54 |
7.06 |
| Q13905 |
PFQLPLGGHP |
6.82
|
3.45 |
3.97 |
|
PFLGPPFQLP |
7.52
|
-0.14 |
0.38 |
|
GHPQPDGPLA |
8.47
|
5.90 |
6.42 |
| P50570 |
PVRIPPGIPP |
7.70
|
6.01 |
6.53 |
|
PPGIPPGVPS |
8.24
|
7.35 |
7.87 |
|
PIPSRPGPQS |
8.27
|
5.10 |
5.62 |
| Q07889 |
YPLKSPGVRP |
8.09
|
5.09 |
5.61 |
|
TSQHIPKLPP |
9.74
|
3.39 |
3.91 |
|
RRHLPSPPLT |
9.80
|
3.76 |
4.28 |
| Q07666 |
RGRGAAPPPP |
6.92
|
0.39 |
0.91 |
|
GRGAAPPPPP |
8.92
|
3.01 |
3.53 |
|
GIQRIPLPPP |
9.22
|
3.75 |
4.27 |
| Q9UKW4 |
PCPCVPKPVD |
12.86
|
5.16 |
5.68 |
| Q9UQC2 |
PRWGSPQQRP |
8.72
|
3.62 |
4.14 |
|
YIPMSPGAHH |
9.37
|
6.61 |
7.13 |
|
SAGHGPRSSP |
9.69
|
4.97 |
5.49 |
| P58107 |
RGPREPGPAG |
6.63
|
4.77 |
5.29 |
|
PRGGEPQGPP |
7.90
|
3.87 |
4.39 |
|
LGAGTPPRPQ |
8.40
|
3.54 |
4.06 |
| P48023 |
SVPRRPGQRR |
7.55
|
4.37 |
4.89 |
|
SPWAPPGTVL |
8.47
|
6.80 |
7.32 |
|
LPPLPLPPLK |
9.14
|
1.83 |
2.35 |
| Q13480 |
PRTFPEGTLG |
9.47
|
6.33 |
6.85 |
|
GFRSSPKTPP |
9.71
|
2.31 |
2.83 |
|
SSPKTPPRRP |
10.59
|
3.09 |
3.61 |
| P27986 |
PKPRPPRPLP |
9.42
|
0.62 |
1.14 |
|
RKKISPPTPK |
9.86
|
3.46 |
3.98 |
|
RPPRPLPVAP |
10.19
|
0.93 |
1.45 |
| O43597 |
RPGLKPAPRP |
8.87
|
3.87 |
4.39 |
|
KECTYPRPLP |
9.49
|
2.38 |
2.90 |
|
PRPGLKPAPR |
10.28
|
1.63 |
2.15 |
| Q13444 |
KSQGPAKPPP |
7.96
|
4.45 |
4.97 |
|
GAGSPLPSWP |
9.52
|
2.18 |
2.70 |
|
GPAKPPPPRK |
9.85
|
4.88 |
5.40 |
| Q06124 |
PDHGVPSDPG |
11.46
|
6.57 |
7.09 |
|
GDQSPLPPCT |
11.51
|
3.87 |
4.39 |
|
LHDGDPNEPV |
12.53
|
7.01 |
7.53 |
| Q8WV28 |
TPASPPGTAS |
8.48
|
6.97 |
7.49 |
|
PRAGKKPTTP |
9.71
|
2.75 |
3.27 |
|
PPPAAPSPLP |
10.27
|
3.04 |
3.56 |
| P04626 |
PREGPLPAAR |
10.34
|
3.24 |
3.76 |
|
QGGAAPQPHP |
10.38
|
4.54 |
5.06 |
|
GLQSLPTHDP |
11.21
|
5.11 |
5.63 |
| P21860 |
GPGIAPGPEP |
5.98
|
4.67 |
5.19 |
|
RRRHSPPHPP |
8.31
|
0.53 |
1.05 |
|
RRHSPPHPPR |
8.88
|
2.17 |
2.69 |
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