ADAN database

 

Scanning Information and Binding Energy of Known Targets

Matrix information:                                                    (Help)
ADAN-name: 1HCS2.PDB
Scoring matrix: 1HCS2_mat
Uniprot code: P12931
Genome source: Homo sapiens
Wild-type ligand: yEEIE
Foldx wt ligand score: 3.64
Foldx random average score for Homo sapiens: 6.811

Available information for P12931 in MINT (Nov 2008):
Nš of interacting proteins: 50
 Proteins belonging to other specie: 11
Nš of interactions described: 106
 Interactions with other species: 20

Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
 Total fragments: 22344792
Proteins after random average filtering: 48054
 Total fragments: 12510712
Proteins after disorder filtering: 37622
 Total fragments: 1544739
Proteins after pattern filtering: 16247
 Total fragments: 50736
Proteins after MINT filtering: 22
 Total fragments: 102


Prediction of know targets:

Ligand peptide Sequence Foldx score ΔGbinding ΔΔG
Reference wt

yEEIE

3.64

-5.28

0.00

Best peptides

DECIy

0.00

-0.78

4.50

         
Interactors      
P49023

YQEIA

4.33

-3.37

1.91

YGVPE

5.76

-1.39

3.89

PLYGV

5.89

-1.90

3.38

Q8WUM4

YNMPY

5.22

-1.18

4.10

PSYPF

5.53

-2.18

3.10

YPPVY

5.55

-1.67

3.61

Q16832

YDRIF

3.54

-2.92

2.36

PYDIF

3.65

-2.75

2.53

YDPML

4.01

-3.36

1.92

P15941

YEKVS

3.79

-2.99

2.29

SEYPT

4.79

-2.61

2.67

YVPPS

5.68

-2.82

2.46

P09848

YDTIG

3.11

-3.51

1.77

YGTAA

6.68

-0.18

5.10

P05106

YMYIS

3.70

-4.26

1.02

SPYMY

5.68

-0.12

5.16

YCNCT

6.09

-1.37

3.91

P00533

YQDPH

5.16

-1.34

3.94

LYNPT

5.81

-2.22

3.06

PDYQQ

6.75

-1.23

4.05

P22681

YMTPS

3.85

-3.88

1.40

YDVPK

4.49

-2.79

2.49

TEYMT

4.59

-1.77

3.51

Q05655

YGKIW

4.73

-1.64

3.64

P03372

PYGPG

5.15

-2.39

2.89

GYTVR

6.38

-1.09

4.19

Q8TBB1

PAYVS

5.62

-2.58

2.70

P25092

TYPVD

6.41

-1.12

4.16

Q05397

YQPVG

4.76

-2.65

2.63

YPSPQ

5.72

-1.36

3.92

YPSPR

6.05

-1.23

4.05

Q9C0H9

PLYGD

5.49

-2.30

2.98

YKAAG

6.02

-0.50

4.78

LYKAA

6.41

-1.30

3.98

P55196

YEPPS

3.97

-3.71

1.57

PYLVE

4.54

-2.15

3.13

ELYNN

4.88

-2.80

2.48

P00519

YPAPK

5.75

-1.48

3.80

VYGVS

6.04

-1.68

3.60

O15455

YLCNT

4.69

-1.29

3.99

SHYLC

6.48

-1.08

4.20

Q13444

GSYVS

6.40

-1.28

4.00

YVSCT

6.42

-1.44

3.84

Q9Y5K6

SVYLS

5.48

-2.60

2.68

CYSPK

6.20

-1.78

3.50

P56945

YQVPG

4.77

-2.85

2.43

YENSE

5.37

-1.40

3.88

QYTPM

5.62

-1.67

3.61

P07550

YSSNG

6.25

-0.74

4.54

AYGNG

6.41

0.13

5.41

P21860

YMPMN

3.28

-3.49

1.79

YEYMN

4.12

-3.24

2.04

YAAMG

4.54

-2.31

2.97

 


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