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Matrix information:
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ADAN-name: 1CSY2.PDB
Scoring matrix: 1CSY2_mat
Uniprot code: P43405
Genome source: Homo sapiens
Wild-type ligand: TyETL
Foldx wt ligand score: 8.93
Foldx random average score for Homo sapiens: 12.904 Available information for P43405 in MINT (Nov 2008):
Nš of interacting proteins: 12
Proteins belonging to other specie: 1
Nš of interactions described: 40
Interactions with other species: 1
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22344792
Proteins after random average filtering: 48056
Total fragments: 14809661
Proteins after disorder filtering: 39107
Total fragments: 2360410
Proteins after pattern filtering: 20334
Total fragments: 140404
Proteins after MINT filtering: 10
Total fragments: 108
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
TyETL |
8.93
|
3.00 |
0.00 |
| Best peptides |
GMGGA |
0.00
|
17.35 |
14.35 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P00533 |
YHNQP |
4.79
|
4.32 |
1.32 |
|
YGCTG |
4.98
|
6.43 |
3.43 |
|
TYGCT |
5.33
|
6.14 |
3.14 |
| P27986 |
GYNET |
6.26
|
6.35 |
3.35 |
|
YNETT |
7.66
|
7.78 |
4.78 |
| P22681 |
GYDVP |
3.32
|
2.53 |
-0.47 |
|
YSVGA |
5.49
|
5.97 |
2.97 |
|
PYSVG |
5.71
|
4.94 |
1.94 |
| P04626 |
YVNQP |
4.26
|
4.39 |
1.39 |
|
TDGYV |
4.31
|
4.53 |
1.53 |
|
YSEDP |
4.45
|
4.04 |
1.04 |
| P21860 |
GGDYA |
2.05
|
5.32 |
2.32 |
|
YAAMG |
3.88
|
4.98 |
1.98 |
|
VNGYV |
5.06
|
4.85 |
1.85 |
| P06239 |
YEGSN |
6.17
|
6.33 |
3.33 |
|
TYEGS |
6.25
|
6.35 |
3.35 |
|
YPIVP |
9.24
|
5.79 |
2.79 |
| P09769 |
SYGAA |
2.64
|
4.83 |
1.83 |
|
YSNFS |
5.01
|
6.56 |
3.56 |
|
IPNYS |
5.84
|
7.91 |
4.91 |
| Q8WV28 |
DYENP |
4.78
|
2.36 |
-0.64 |
|
SYEPP |
5.46
|
3.44 |
0.44 |
|
RRDYA |
7.54
|
5.83 |
2.83 |
| O00459 |
SHYRP |
9.80
|
6.89 |
3.89 |
| Q15303 |
GYMTP |
4.16
|
3.20 |
0.20 |
|
YVSDC |
4.75
|
6.38 |
3.38 |
|
YWNHS |
5.09
|
7.87 |
4.87 |
|
