ADAN database

Scanning Information and Binding Energy of Known Targets

Matrix information: (Help)
ADAN-name: 1BF52.PDB
Scoring matrix: 1BF52_mat
Uniprot code: P42224
Genome source: Homo sapiens
Wild-type ligand: GYIKTELISV
Foldx wt ligand score: 5.45
Foldx random average score for Homo sapiens: 5.300

Available information for P42224 in MINT (Nov 2008):
Nº of interacting proteins: 21
Proteins belonging to other specie: 3
Nº of interactions described: 50
Interactions with other species: 9

Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22104514
Proteins after random average filtering: 48046
Total fragments: 11521927
Proteins after disorder filtering: 35504
Total fragments: 1041713
Proteins after pattern filtering: 18165
Total fragments: 122708
Proteins after MINT filtering: 9
Total fragments: 75

Prediction of know targets:

Ligand peptide	Sequence	Foldx score	ΔGbinding	ΔΔG
Reference wt	GYIKTELISV	5.45	0.34	0.00
Best peptides	RRpRGHKMKG	0.00	6.58	6.24

Interactors
P19438	QGKYIHPQNN	4.14	-1.04	-1.38
	PQGKYIHPQN	4.21	-0.81	-1.15
	YNDCPGPGQD	4.39	-0.87	-1.21
O75925	MTPMPYDLQG	3.55	-0.76	-1.10
	LTYDGHPASS	3.71	0.04	-0.30
	GYLPPTKNGV	3.78	1.68	1.34
Q8N6P7	WPPSYGVCME	3.56	-1.04	-1.38
	SPLSYAPNAA	3.86	1.26	0.92
	PPSYGVCMEG	3.97	-1.01	-1.35
P04626	NPEYLTPQGG	3.95	0.60	0.26
	PEYLTPQGGA	4.12	1.55	1.21
	FDNLYYWDQD	4.15	-0.41	-0.75
Q92793	QGPGGYPPAM	3.93	0.07	-0.27
	GMPYPTPAMQ	4.26	-1.03	-1.37
	CPPSEGDDYI	4.96	-0.10	-0.44
P35368	SPGYLGRGAP	4.42	-1.02	-1.36
	SPSPGYLGRG	4.47	-2.05	-2.39
	ASPSPGYLGR	4.55	1.26	0.92
P29597	AVYRCGPPGT	4.01	1.10	0.76
	REPAVYRCGP	4.03	-0.87	-1.21
	YCYDPTNDGT	4.37	2.59	2.25
P48551	DYSSTEGSGG	4.42	1.22	0.88
	EEDYSSTEGS	4.80	2.15	1.81
	YSSTEGSGGR	4.86	2.20	1.86
P38398	DRWYMHSCSG	3.84	-0.17	-0.51
	PSLDDRWYMH	4.14	-1.72	-2.06
	DDRWYMHSCS	4.17	-1.64	-1.98