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Matrix information:
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ADAN-name: 1AOT2.PDB
Scoring matrix: 1AOT2_mat
Uniprot code: P06241
Genome source: Homo sapiens
Wild-type ligand: EPQyEEIPIYL
Foldx wt ligand score: 20.71
Foldx random average score for Homo sapiens: 18.074 Available information for P06241 in MINT (Nov 2008):
Nš of interacting proteins: 29
Proteins belonging to other specie: 8
Nš of interactions described: 52
Interactions with other species: 15
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22056464
Proteins after random average filtering: 48038
Total fragments: 12955018
Proteins after disorder filtering: 35528
Total fragments: 1659015
Proteins after pattern filtering: 19687
Total fragments: 246099
Proteins after MINT filtering: 12
Total fragments: 182
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
EPQyEEIPIYL |
20.71
|
-3.90 |
0.00 |
| Best peptides |
yDsyGYIyGyy |
0.00
|
13.18 |
17.08 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P54253 |
AYATPQPGTPV |
11.40
|
1.43 |
5.33 |
|
LSTGLDYSPPS |
12.48
|
2.99 |
6.89 |
|
VVVHPSPSDYS |
13.09
|
0.75 |
4.65 |
| P11137 |
SMDEGDDYLPA |
7.35
|
0.77 |
4.67 |
|
AITPGTPPSYS |
10.15
|
-0.03 |
3.87 |
|
HGSQGTYSNTK |
10.26
|
0.80 |
4.70 |
| O15117 |
QLDMGDEVYDD |
6.54
|
-0.45 |
3.45 |
|
DIYDGIEEEDA |
6.69
|
-0.75 |
3.15 |
|
YNTGGNPTEDV |
7.34
|
0.57 |
4.47 |
| P22681 |
NEDDGYDVPKP |
6.67
|
1.24 |
5.14 |
|
EEDTEYMTPSS |
9.70
|
-1.83 |
2.07 |
|
ESENEDDGYDV |
9.86
|
-5.11 |
-1.21 |
| Q07666 |
SQSQGDSEYYD |
10.69
|
1.56 |
5.46 |
|
SQGDSEYYDYG |
12.48
|
-0.91 |
2.99 |
|
YYSQSQGDSEY |
14.94
|
0.68 |
4.58 |
| Q13283 |
YVHGGLDSNGK |
8.24
|
1.98 |
5.88 |
|
SYVHGGLDSNG |
10.22
|
2.62 |
6.52 |
|
KNSSYVHGGLD |
14.53
|
1.14 |
5.04 |
| Q13444 |
NRHCYCEEGWA |
10.98
|
1.99 |
5.89 |
|
RNPSGSYVSCT |
11.32
|
3.77 |
7.67 |
|
GVCDSNRHCYC |
13.37
|
0.59 |
4.49 |
| P42768 |
SRYRGLPAPGP |
9.67
|
0.91 |
4.81 |
|
YRGLPAPGPSP |
14.03
|
-0.29 |
3.61 |
|
ITSSRYRGLPA |
16.27
|
1.17 |
5.07 |
| P16333 |
GSYNGQVGWFP |
9.17
|
2.71 |
6.61 |
|
GQVGWFPSNYV |
10.24
|
-0.13 |
3.77 |
|
QCDYIRPSLTG |
10.80
|
-3.93 |
-0.03 |
| Q9Y5K6 |
SSGTVYPKRPE |
10.44
|
-0.24 |
3.66 |
|
KDTCYSPKPSV |
11.43
|
0.30 |
4.20 |
|
KKDTCYSPKPS |
11.61
|
-0.06 |
3.84 |
| P29353 |
QYYNDFPGKEP |
9.71
|
0.00 |
3.90 |
|
HQYYNDFPGKE |
11.09
|
2.87 |
6.77 |
|
EPPDHQYYNDF |
11.43
|
-0.50 |
3.40 |
| P35968 |
NQTSGYQSGYH |
9.81
|
3.41 |
7.31 |
|
SGYQSGYHSDD |
12.77
|
1.90 |
5.80 |
|
EGSNQTSGYQS |
14.04
|
1.00 |
4.90 |
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