ADAN database

 

Scanning Information and Binding Energy of Known Targets

Matrix information:                                                    (Help)
ADAN-name: 1A813.PDB
Scoring matrix: 1A813_mat
Uniprot code: P43405
Genome source: Homo sapiens
Wild-type ligand: PDyEPIRKG
Foldx wt ligand score: 5.51
Foldx random average score for Homo sapiens: 10.885

Available information for P43405 in MINT (Nov 2008):
Nš of interacting proteins: 12
 Proteins belonging to other specie: 1
Nš of interactions described: 40
 Interactions with other species: 1

Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
 Total fragments: 22152566
Proteins after random average filtering: 48050
 Total fragments: 12030549
Proteins after disorder filtering: 35903
 Total fragments: 1062335
Proteins after pattern filtering: 18832
 Total fragments: 114400
Proteins after MINT filtering: 10
 Total fragments: 103


Prediction of know targets:

Ligand peptide Sequence Foldx score ΔGbinding ΔΔG
Reference wt

PDyEPIRKG

5.51

-9.30

0.00

Best peptides

EsyLyMyKR

0.00

-7.56

1.74

         
Interactors      
P00533

PTTYQMDVN

7.18

-5.05

4.25

GSVQNPVYH

8.51

-3.40

5.90

YGCTGPGLE

8.92

-0.29

9.01

P27986

GYNETTGER

9.91

-2.13

7.17

P22681

EDTEYMTPS

6.28

-4.41

4.89

DRPYSVGAE

7.49

-2.70

6.60

EGAPSPNYD

8.53

-1.71

7.59

P04626

EYVNQPDVR

7.36

-3.65

5.65

PSPLQRYSE

7.68

-4.14

5.16

PNPEGRYTF

8.13

-3.28

6.02

P21860

EEDVNGYVM

7.56

-3.11

6.19

GGDYAAMGA

7.80

-2.55

6.75

EDYEYMNRQ

7.99

-6.33

2.97

P06239

LVTYEGSNP

8.58

-1.56

7.74

YPIVPLDGK

9.96

-5.28

4.02

P09769

ADHYGPDPT

8.79

-2.18

7.12

SFAHIPNYS

8.79

-0.56

8.74

FRSYGAADH

9.54

-0.74

8.56

Q8WV28

SDDFDSDYE

9.13

-3.21

6.09

ENYIHPTES

9.37

-3.86

5.44

DDSYEPPPV

9.70

-2.87

6.43

O00459

YRPELPAPR

8.01

-2.73

6.57

Q15303

DCIYYPWTG

6.15

-3.96

5.34

ELDEEGYMT

7.19

-2.94

6.36

GRCYGPYVS

7.60

-3.36

5.94

 


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