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Matrix information:
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ADAN-name: 1A372.PDB
Scoring matrix: 1A372_mat
Uniprot code: P63104
Genome source: Homo sapiens
Wild-type ligand: RSTsTPN
Foldx wt ligand score: 32.0
Foldx random average score for Homo sapiens: 30.326 Available information for P63104 in MINT (Nov 2008):
Nš of interacting proteins: 310
Proteins belonging to other specie: 3
Nš of interactions described: 374
Interactions with other species: 6
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having weird amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22248677
Proteins after random average filtering: 48047
Total fragments: 10806026
Proteins after disorder filtering: 37395
Total fragments: 1856723
Proteins after pattern filtering: 3670
Total fragments: 5980
Proteins after MINT filtering: 32
Total fragments: 88 ROC parameters:
TPR= 0.103
FPR= 0.076
ACC= 0.919
SPC= 0.924
MCC= 0.008 Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
RSTsTPN |
32.00
|
-0.01 |
0.00 |
| Best peptides |
GGGGGGN |
0.00
|
3.28 |
3.29 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| Q7Z401 |
RPPSTGV |
27.81
|
0.68 |
0.69 |
|
DRPPSTG |
29.28
|
0.46 |
0.47 |
| O75592 |
RAESPGP |
20.32
|
-2.60 |
-2.59 |
| Q5T200 |
RSHTSGR |
23.16
|
-0.27 |
-0.26 |
|
RSSSLGS |
23.35
|
0.67 |
0.68 |
|
RTLTPPL |
29.31
|
1.13 |
1.14 |
| P54253 |
GRTASPP |
27.03
|
3.52 |
3.53 |
|
RTASPPA |
29.42
|
1.02 |
1.03 |
| Q15007 |
RQRTSGS |
26.67
|
0.78 |
0.79 |
| P58340 |
RMRSVGH |
30.32
|
3.53 |
3.54 |
| P16471 |
RPGTDGG |
18.75
|
-2.72 |
-2.71 |
|
WRPGTDG |
23.38
|
3.97 |
3.98 |
| Q9UDY2 |
RLNSHGG |
26.91
|
7.81 |
7.82 |
| O75044 |
RSDSHGL |
23.85
|
0.96 |
0.97 |
| Q08211 |
RGNSGGD |
13.36
|
-0.90 |
-0.89 |
|
RGPSGGY |
17.82
|
-0.71 |
-0.70 |
|
YRGPSGG |
23.70
|
1.39 |
1.40 |
| O60825 |
RNYSVGS |
26.47
|
4.63 |
4.64 |
| P15924 |
RASSKGG |
21.15
|
0.54 |
0.55 |
| Q7KZI7 |
RPSTAPQ |
30.10
|
-0.28 |
-0.27 |
| Q86YZ3 |
RSSSSGR |
21.05
|
2.05 |
2.06 |
|
RSSSSGQ |
21.79
|
2.28 |
2.29 |
|
RSSSSGP |
22.48
|
0.99 |
1.00 |
| P26358 |
RSKSDGE |
23.99
|
1.41 |
1.42 |
| Q7Z6B7 |
RSTSSGQ |
21.90
|
1.88 |
1.89 |
|
RRSTSSG |
29.02
|
1.47 |
1.48 |
| Q9Y4H2 |
RPWTPGQ |
27.31
|
-3.68 |
-3.67 |
| Q6DD88 |
RGGSDPE |
20.15
|
-1.96 |
-1.95 |
|
WRGGSDP |
20.66
|
0.19 |
0.20 |
| P49815 |
RSMSGGH |
23.92
|
1.65 |
1.66 |
| O96013 |
SREGSGG |
18.99
|
-0.65 |
-0.64 |
|
REGSGGP |
24.56
|
0.58 |
0.59 |
| Q14764 |
RRVASGP |
20.86
|
2.48 |
2.49 |
|
RVASGPS |
27.53
|
0.57 |
0.58 |
| Q7L8J4 |
GRRGSDG |
24.56
|
1.09 |
1.10 |
|
RRGSDGG |
25.61
|
-0.32 |
-0.31 |
| Q15154 |
RSTSAPS |
28.22
|
2.17 |
2.18 |
| Q9UQ35 |
SRSGSSP |
23.12
|
1.34 |
1.35 |
|
RSSTGPE |
23.51
|
-0.27 |
-0.26 |
|
RCRSPGM |
24.95
|
2.14 |
2.15 |
| P55196 |
PRPASDG |
22.31
|
0.31 |
0.32 |
|
RPDSGGT |
23.28
|
0.17 |
0.18 |
|
RPASDGV |
23.63
|
-0.19 |
-0.18 |
| P30291 |
ARSPTEP |
29.73
|
1.85 |
1.86 |
| Q6Y7W6 |
RSSSRGR |
28.84
|
2.10 |
2.11 |
|
GRSSSRG |
29.90
|
2.33 |
2.34 |
| Q96RK0 |
RPESVGG |
24.07
|
-0.17 |
-0.16 |
|
RLHTVGG |
26.17
|
3.74 |
3.75 |
|
ARVPSAP |
29.20
|
-1.63 |
-1.62 |
| O95644 |
RGETLGP |
18.32
|
-3.12 |
-3.11 |
| Q8WUI4 |
RAQSSPA |
29.23
|
-0.86 |
-0.85 |
| P34931 |
GRPATGP |
22.59
|
3.62 |
3.63 |
| Q5T5U3 |
RTTSPPL |
28.73
|
0.98 |
0.99 |
|
