4. Different looks and tools for the same entry....

• Starting with the UniProt server: (http://www.uniprot.org/):
• Look for the amino acid sequence of human carbonic anhydrase 2.
• Get the corresponding nucleic acid entries in EMBL and GenBank: try to find a nucleic acid sequence derived from genomic DNA sequencing and another one derived from cDNA sequencing.
• From the UniProtKB/Swiss-Prot entry, look at the data available for variant Pro-92 and in particular its position in the 3D structure (Use the “Astex viewer”).

• Starting with the NCBI server: (http://www.ncbi.nlm.nih.gov/):
• Look for the amino acid sequence of human carbonic anhydrase 2 using ENTREZ Protein.
• Find the UniProtKB/Swiss-Prot entry and as above:
• Get the corresponding nucleic acid entries in EMBL and GenBank.
• Find the data available for the variant Pro-92.

Uniprot: human carbonic anhydrase 2
Uniprot: human carbonic anhydrase 2 -> nucleic acid cross-references
Uniprot: human carbonic anhydrase 2 -> natural variations are described in the 'Sequence annotation (Features)' section

• click on the Q → P in OPTB3 link
• then chose the 'Astex Viewer'

NCBI: human carbonic anhydrase 2
Note that there is no direct link to the 'variant page'