INTERNAL ADAN INFORMATION

• Record: 3505
• Number: 58
• Inclusion date: 20-IV-2008

WHOLE PROTEIN INFORMATION

• Domains within protein: STXB4_HUMAN by SMART
• Basic UniProtKB Entry: STXB4_HUMAN
• InterPro link: STXB4_HUMAN
• Swiss-Prot ENTRY: STXB4_HUMAN
• Swiss-Prot AC number: Q6ZWJ1
• Sequence: Q6ZWJ1
• Pfam database: STXB4_HUMAN

ALIGNMENT

• BLAST against Swiss-Prot: Q6ZWJ1
• BLAST for whole protein: Q6ZWJ1
• SAS for whole protein: Q6ZWJ1
• BLAST for modular domain: 2YSG
• SAS for domain: 2YSG

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: no ligand 
• iPfam: WW
• PsiBase: 2YSG
• MINT: whole protein: Q6ZWJ1 or domain: 2YSG
• DOMINO database: Q6ZWJ1
• APID: Q6ZWJ1

• Title: Solution Structure Of The Ww Domain From The Human Syntaxin- Binding Protein 4
• Experimental Technique: nmr
• Resolution Å: n/a
• Protein Source: Homo sapiens
• Reference:
• Sequence domain: SeqA_2YSG2.txt
• Peptide sequence of ligand:
• Biochemical affinity data for: 2YSG
• Drugs:
• Phosphorylated residue type: Phosphorylated on Ser-99 by PKB/AKT2 after insulin treatment. Phosphorylation on Ser-99 abolishes the interaction with STX4A (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR
• Pfam family: WW
• Pfam structure: 2YSG
• RCSB_PDB_ID: 2YSG
• SMART: WW
• PDBsum (domain): 2YSG
• PDBsum (Ligand): 2YSG
• MSD (summary): 2YSG
• MSD (ligands): 2YSG
• Molecular Surface: 2YSG

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.