INTERNAL ADAN INFORMATION

• Record: 3358
• Number: 32
• Inclusion date: 20-IV-2008

WHOLE PROTEIN INFORMATION

• Domains within protein: RNF8_HUMAN by SMART
• Basic UniProtKB Entry: RNF8_HUMAN
• InterPro link: RNF8_HUMAN
• Swiss-Prot ENTRY: RNF8_HUMAN
• Swiss-Prot AC number: O76064
• Sequence: O76064
• Pfam database: RNF8_HUMAN

ALIGNMENT

• BLAST against Swiss-Prot: O76064
• BLAST for whole protein: O76064
• SAS for whole protein: O76064
• BLAST for modular domain: 2PIE
• SAS for domain: 2PIE

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: 2PIE2_mat 
• iPfam: FHA
• PsiBase: 2PIE
• MINT: whole protein: O76064 or domain: 2PIE
• DOMINO database: O76064
• APID: O76064

• Title: Crystal Structure Of The Fha Domain Of Rnf8 In Complex With Its Optimal Phosphopeptide
• Experimental Technique: x-ray
• Resolution Å: 1.35
• Protein Source: Homo sapiens
• Reference: Cell(Cambridge,Mass.) v131 pp. 901-14, 2007
• Sequence domain: SeqA_2PIE2.txt
• Peptide sequence of ligand: ELKpERY
• Biochemical affinity data for: 2PIE
• Drugs:
• Phosphorylated residue type: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger
• Pfam family: FHA
• Pfam structure: 2PIE
• RCSB_PDB_ID: 2PIE
• SMART: FHA
• PDBsum (domain): 2PIE
• PDBsum (Ligand): 2PIE
• MSD (summary): 2PIE
• MSD (ligands): 2PIE
• Molecular Surface: 2PIE

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.