INTERNAL ADAN INFORMATION

• Record: 3243
• Number: 361
• Inclusion date: 20-IV-2008

WHOLE PROTEIN INFORMATION

• Domains within protein: SRC_CHICK by SMART
• Basic UniProtKB Entry: SRC_CHICK
• InterPro link: SRC_CHICK
• Swiss-Prot ENTRY: SRC_CHICK
• Swiss-Prot AC number: P00523
• Sequence: P00523
• Pfam database: SRC_CHICK

ALIGNMENT

• BLAST against Swiss-Prot: P00523
• BLAST for whole protein: P00523
• SAS for whole protein: P00523
• BLAST for modular domain: 2PTK
• SAS for domain: 2PTK

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: 2PTK2_mat 
• iPfam: SH3
• PsiBase: 2PTK
• MINT: whole protein: P00523 or domain: 2PTK
• DOMINO database: P00523
• APID: P00523

• Title: Chicken Src Tyrosine Kinase
• Experimental Technique: x-ray diffraction
• Resolution Å: 2.35
• Protein Source: Gallus gallus
• Reference: J.Mol.Biol. v274 pp. 757-75, 1997
• Sequence domain: SeqA_2PTK2.txt
• Peptide sequence of ligand: KPQTQGLAK
• Biochemical affinity data for: 2PTK
• Drugs:
• Phosphorylated residue type: Phosphorylated on Tyr-527 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity (By similarity)
• Pfam family: SH3
• Pfam structure: 2PTK
• RCSB_PDB_ID: 2PTK
• SMART: SH3
• PDBsum (domain): 2PTK
• PDBsum (Ligand): 2PTK
• MSD (summary): 2PTK
• MSD (ligands): 2PTK
• Molecular Surface: 2PTK

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.