INTERNAL ADAN INFORMATION

• Record: 3211
• Number: 329
• Inclusion date: 20-IV-2008

WHOLE PROTEIN INFORMATION

• Domains within protein: CRK_MOUSE by SMART
• Basic UniProtKB Entry: CRK_MOUSE
• InterPro link: CRK_MOUSE
• Swiss-Prot ENTRY: CRK_MOUSE
• Swiss-Prot AC number: Q64010
• Sequence: Q64010
• Pfam database: CRK_MOUSE

ALIGNMENT

• BLAST against Swiss-Prot: Q64010
• BLAST for whole protein: Q64010
• SAS for whole protein: Q64010
• BLAST for modular domain: 2GGR
• SAS for domain: 2GGR

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: no ligand 
• iPfam: SH3
• PsiBase: 2GGR
• MINT: whole protein: Q64010 or domain: 2GGR
• DOMINO database: Q64010
• APID: Q64010

• Title: Solution Structure Of The C-Terminal Sh3 Domain Of C-Crkii
• Experimental Technique: nmr
• Resolution Å: n/a
• Protein Source: Mus musculus
• Reference: Biochemistry v45 pp. 8874-84, 2006
• Sequence domain: SeqA_2GGR2.txt
• Peptide sequence of ligand:
• Biochemical affinity data for: 2GGR
• Drugs:
• Phosphorylated residue type: Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway
• Pfam family: SH3
• Pfam structure: 2GGR
• RCSB_PDB_ID: 2GGR
• SMART: SH3
• PDBsum (domain): 2GGR
• PDBsum (Ligand): 2GGR
• MSD (summary): 2GGR
• MSD (ligands): 2GGR
• Molecular Surface: 2GGR

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.