INTERNAL ADAN INFORMATION

• Record: 3141
• Number: 214
• Inclusion date: 20-IV-2008

WHOLE PROTEIN INFORMATION

• Domains within protein: ZAP70_HUMAN by SMART
• Basic UniProtKB Entry: ZAP70_HUMAN
• InterPro link: ZAP70_HUMAN
• Swiss-Prot ENTRY: ZAP70_HUMAN
• Swiss-Prot AC number: P43403
• Sequence: P43403
• Pfam database: ZAP70_HUMAN

ALIGNMENT

• BLAST against Swiss-Prot: P43403
• BLAST for whole protein: P43403
• SAS for whole protein: P43403
• BLAST for modular domain: 2OQ1
• SAS for domain: 2OQ1

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: 2OQ12_mat 
• iPfam: SH2
• PsiBase: 2OQ1
• MINT: whole protein: P43403 or domain: 2OQ1
• DOMINO database: P43403
• APID: P43403

• Title: Tandem Sh2 Domains Of Zap-70 With 19-Mer Zeta1 Peptide
• Experimental Technique: x-ray diffraction
• Resolution Å: 1.9
• Protein Source: Homo sapiens
• Reference: Nature v377 pp. 32-8, 1995
• Sequence domain: SeqA_2OQ12.txt
• Peptide sequence of ligand: NQLyNELNLG
• Biochemical affinity data for: 2OQ1
• Drugs:
• Phosphorylated residue type: Phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation. Tyr-319 phosphorylation is essential for full activity
• Pfam family: SH2
• Pfam structure: 2OQ1
• RCSB_PDB_ID: 2OQ1
• SMART: SH2
• PDBsum (domain): 2OQ1
• PDBsum (Ligand): 2OQ1
• MSD (summary): 2OQ1
• MSD (ligands): 2OQ1
• Molecular Surface: 2OQ1

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.