INTERNAL ADAN INFORMATION

• Record: 3138
• Number: 211
• Inclusion date: 20-IV-2008

WHOLE PROTEIN INFORMATION

• Domains within protein: GRB2_HUMAN by SMART
• Basic UniProtKB Entry: GRB2_HUMAN
• InterPro link: GRB2_HUMAN
• Swiss-Prot ENTRY: GRB2_HUMAN
• Swiss-Prot AC number: P62993
• Sequence: P62993
• Pfam database: GRB2_HUMAN

ALIGNMENT

• BLAST against Swiss-Prot: P62993
• BLAST for whole protein: P62993
• SAS for whole protein: P62993
• BLAST for modular domain: 2HUW
• SAS for domain: 2HUW

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: no ligand 
• iPfam: SH2
• PsiBase: 2HUW
• MINT: whole protein: P62993 or domain: 2HUW
• DOMINO database: P62993
• APID: P62993

• Title: X-Ray Crystal Structure Of The Grb2 Sh2 Domain Complexed To A Constrained And Cyclopropane-Derived Ligand
• Experimental Technique: x-ray diffraction
• Resolution Å: 1.9
• Protein Source: Homo sapiens
• Reference: Angew.Chem.Int.Ed.Engl. v45 pp. 6830-5, 2006
• Sequence domain: SeqA_2HUW2.txt
• Peptide sequence of ligand:
• Biochemical affinity data for: 2HUW
• Drugs:
• Phosphorylated residue type:
• Pfam family: SH2
• Pfam structure: 2HUW
• RCSB_PDB_ID: 2HUW
• SMART: SH2
• PDBsum (domain): 2HUW
• PDBsum (Ligand): 2HUW
• MSD (summary): 2HUW
• MSD (ligands): 2HUW
• Molecular Surface: 2HUW

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.