INTERNAL ADAN INFORMATION

• Record: 3137
• Number: 210
• Inclusion date: 20-IV-2008

WHOLE PROTEIN INFORMATION

• Domains within protein: SOCS3_MOUSE by SMART
• Basic UniProtKB Entry: SOCS3_MOUSE
• InterPro link: SOCS3_MOUSE
• Swiss-Prot ENTRY: SOCS3_MOUSE
• Swiss-Prot AC number: O35718
• Sequence: O35718
• Pfam database: SOCS3_MOUSE

ALIGNMENT

• BLAST against Swiss-Prot: O35718
• BLAST for whole protein: O35718
• SAS for whole protein: O35718
• BLAST for modular domain: 2HMH
• SAS for domain: 2HMH

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: 2HMH2_mat 
• iPfam: SH2
• PsiBase: 2HMH
• MINT: whole protein: O35718 or domain: 2HMH
• DOMINO database: O35718
• APID: O35718

• Title: Crystal Structure Of Socs3 In Complex With Gp130(Ptyr757) Phosphopeptide.
• Experimental Technique: x-ray diffraction
• Resolution Å: 2.0
• Protein Source: Mus musculus
• Reference: Structure v14 pp. 1285-92, 2006
• Sequence domain: SeqA_2HMH2.txt
• Peptide sequence of ligand: STVEySTVVHS
• Biochemical affinity data for: 2HMH
• Drugs:
• Phosphorylated residue type: Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1 (By similarity)
• Pfam family: SH2
• Pfam structure: 2HMH
• RCSB_PDB_ID: 2HMH
• SMART: SH2
• PDBsum (domain): 2HMH
• PDBsum (Ligand): 2HMH
• MSD (summary): 2HMH
• MSD (ligands): 2HMH
• Molecular Surface: 2HMH

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.