INTERNAL ADAN INFORMATION

• Record: 3134
• Number: 207
• Inclusion date: 20-IV-2008

WHOLE PROTEIN INFORMATION

• Domains within protein: SRC_HUMAN by SMART
• Basic UniProtKB Entry: SRC_HUMAN
• InterPro link: SRC_HUMAN
• Swiss-Prot ENTRY: SRC_HUMAN
• Swiss-Prot AC number: P12931
• Sequence: P12931
• Pfam database: SRC_HUMAN

ALIGNMENT

• BLAST against Swiss-Prot: P12931
• BLAST for whole protein: P12931
• SAS for whole protein: P12931
• BLAST for modular domain: 2H8H
• SAS for domain: 2H8H

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: 2H8H2_mat 
• iPfam: SH2
• PsiBase: 2H8H
• MINT: whole protein: P12931 or domain: 2H8H
• DOMINO database: P12931
• APID: P12931

• Title: Src Kinase In Complex With A Quinazoline Inhibitor
• Experimental Technique: x-ray diffraction
• Resolution Å: 2.2
• Protein Source: Homo sapiens
• Reference: J.Med.Chem. v49 pp. 6465-88, 2006
• Sequence domain: SeqA_2H8H2.txt
• Peptide sequence of ligand: DYFTSTEPQyQP
• Biochemical affinity data for: 2H8H
• Drugs:
• Phosphorylated residue type: Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity
• Pfam family: SH2
• Pfam structure: 2H8H
• RCSB_PDB_ID: 2H8H
• SMART: SH2
• PDBsum (domain): 2H8H
• PDBsum (Ligand): 2H8H
• MSD (summary): 2H8H
• MSD (ligands): 2H8H
• Molecular Surface: 2H8H

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.