INTERNAL ADAN INFORMATION

• Record: 3133
• Number: 206
• Inclusion date: 20-IV-2008

WHOLE PROTEIN INFORMATION

• Domains within protein: GRB2_HUMAN by SMART
• Basic UniProtKB Entry: GRB2_HUMAN
• InterPro link: GRB2_HUMAN
• Swiss-Prot ENTRY: GRB2_HUMAN
• Swiss-Prot AC number: P62993
• Sequence: P62993
• Pfam database: GRB2_HUMAN

ALIGNMENT

• BLAST against Swiss-Prot: P62993
• BLAST for whole protein: P62993
• SAS for whole protein: P62993
• BLAST for modular domain: 2H5K
• SAS for domain: 2H5K

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: 2H5K2_mat 
• iPfam: SH2
• PsiBase: 2H5K
• MINT: whole protein: P62993 or domain: 2H5K
• DOMINO database: P62993
• APID: P62993

• Title: Crystal Structure Of Complex Between The Domain-Swapped Dimeric Grb2 Sh2 Domain And Shc-Derived Ligand, Ac-Nh-Ptyr- Val-Asn-Nh2
• Experimental Technique: x-ray diffraction
• Resolution Å: 3.25
• Protein Source: Homo sapiens
• Reference: Arch.Biochem.Biophys. v462 pp. 47-53, 2007
• Sequence domain: SeqA_2H5K2.txt
• Peptide sequence of ligand: yVN
• Biochemical affinity data for: 2H5K
• Drugs:
• Phosphorylated residue type:
• Pfam family: SH2
• Pfam structure: 2H5K
• RCSB_PDB_ID: 2H5K
• SMART: SH2
• PDBsum (domain): 2H5K
• PDBsum (Ligand): 2H5K
• MSD (summary): 2H5K
• MSD (ligands): 2H5K
• Molecular Surface: 2H5K

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.