INTERNAL ADAN INFORMATION

• Record: 3131
• Number: 204
• Inclusion date: 20-IV-2008

WHOLE PROTEIN INFORMATION

• Domains within protein: BTK_HUMAN by SMART
• Basic UniProtKB Entry: BTK_HUMAN
• InterPro link: BTK_HUMAN
• Swiss-Prot ENTRY: BTK_HUMAN
• Swiss-Prot AC number: Q06187
• Sequence: Q06187
• Pfam database: BTK_HUMAN

ALIGNMENT

• BLAST against Swiss-Prot: Q06187
• BLAST for whole protein: Q06187
• SAS for whole protein: Q06187
• BLAST for modular domain: 2GE9
• SAS for domain: 2GE9

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: no ligand 
• iPfam: SH2
• PsiBase: 2GE9
• MINT: whole protein: Q06187 or domain: 2GE9
• DOMINO database: Q06187
• APID: Q06187

• Title: Solution Structures Of The Sh2 Domain Of Bruton'S Tyrosine Kinase
• Experimental Technique: nmr
• Resolution Å: n/a
• Protein Source: Homo sapiens
• Reference: J.Biomol.Nmr v36 pp. 73-8, 2006
• Sequence domain: SeqA_2GE92.txt
• Peptide sequence of ligand:
• Biochemical affinity data for: 2GE9
• Drugs:
• Phosphorylated residue type: Autophosphorylated on Tyr-223 and Tyr-551. Phosphorylation of Tyr-223 may create a docking site for a SH2 containing protein (By similarity)
• Pfam family: SH2
• Pfam structure: 2GE9
• RCSB_PDB_ID: 2GE9
• SMART: SH2
• PDBsum (domain): 2GE9
• PDBsum (Ligand): 2GE9
• MSD (summary): 2GE9
• MSD (ligands): 2GE9
• Molecular Surface: 2GE9

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.