INTERNAL ADAN INFORMATION

• Record: 3119
• Number: 192
• Inclusion date: 20-IV-2008

WHOLE PROTEIN INFORMATION

• Domains within protein: HCK_HUMAN by SMART
• Basic UniProtKB Entry: HCK_HUMAN
• InterPro link: HCK_HUMAN
• Swiss-Prot ENTRY: HCK_HUMAN
• Swiss-Prot AC number: P08631
• Sequence: P08631
• Pfam database: HCK_HUMAN

ALIGNMENT

• BLAST against Swiss-Prot: P08631
• BLAST for whole protein: P08631
• SAS for whole protein: P08631
• BLAST for modular domain: 2C0T
• SAS for domain: 2C0T

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: 2C0T2_mat 
• iPfam: SH2
• PsiBase: 2C0T
• MINT: whole protein: P08631 or domain: 2C0T
• DOMINO database: P08631
• APID: P08631

• Title: Src Family Kinase Hck With Bound Inhibitor A-641359
• Experimental Technique: x-ray diffraction
• Resolution Å: 2.15
• Protein Source: Homo sapiens
• Reference: Bioorg.Med.Chem.Lett. v16 pp. 118-22, 2006
• Sequence domain: SeqA_2C0T2.txt
• Peptide sequence of ligand: TATESQyEEIP
• Biochemical affinity data for: 2C0T
• Drugs:
• Phosphorylated residue type: Isoform p59-HCK contains a N-myristoyl glycine at position 3 (By similarity). Isoform p59-HCK contains a S-palmitoyl cysteine at position 3 (By similarity)
• Pfam family: SH2
• Pfam structure: 2C0T
• RCSB_PDB_ID: 2C0T
• SMART: SH2
• PDBsum (domain): 2C0T
• PDBsum (Ligand): 2C0T
• MSD (summary): 2C0T
• MSD (ligands): 2C0T
• Molecular Surface: 2C0T

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.